ArticleFrontiers in medicine2026
Creatinine clearance rate predicts all-cause and cardiovascular mortality in patients with MASLD: a Shanghai cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent chronic liver condition globally, driving the need to identify prognostic risk factors. The creatinine clearance rate (CCR) serves as a sensitive early marker of glomerular filtration rate. Yet evidence regarding its specific association with mortality in MASLD patients remains limited. Method: The predictive value of the CCR for long-term survival was evaluated in a five-year cohort of adults with MASLD from Pudong District, Shanghai. Baseline characteristics were analyzed, and Kaplan-Meier survival analysis, LASSO regression, restricted cubic splines (RCS), and Cox proportional hazards models were employed to assess the relationship between the CCR and mortality risk, with sensitivity analyses conducted to test robustness. Results: Among 8,828 MASLD patients, a higher CCR was inversely associated with cardiovascular mortality (HR = 0.95; 95% CI: 0.95-0.96) and all-cause mortality (HR = 0.97; 95% CI: 0.96-0.97) (both Conclusion: In this cohort of Shanghai adults with MASLD, a higher estimated creatinine clearance rate was independently associated with a significantly reduced risk of all-cause and cardiovascular mortality. CCR may serve as a valuable renal function-related prognostic marker for risk stratification in the MASLD population.
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