SynthesisFrontiers in medicine2026
From regeneration to immunomodulation: a 20-year global bibliometric analysis of platelet-rich plasma for osteoarthritis.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [Soft tissue engineering in orthopedics : Regenerative synergistic effects of shockwave therapy, PRP, EMTT, and hyaluronic acid].Orthopadie (Heidelberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoarthritis (OA) is a whole-joint disease driven by complex immunopathogenic mechanisms and chronic inflammation, positioning platelet-rich plasma (PRP) as an emerging therapy of significant interest. Objective: This study conducts a bibliometric analysis to systematically map the global research landscape, hotspots, and immunological trends of PRP for the treatment of OA from 2004 to 2024. Methods: We analyzed 1,862 articles and reviews retrieved from the Web of Science Core Collection (WoSCC) for bibliometric mapping, complemented by 148 clinical trial records from PubMed for qualitative analysis. We utilized VOSviewer, CiteSpace, and the R-package bibliometrix for visual analysis of countries, institutions, authors, journals, and keywords. Results: The results demonstrate a significant growth in annual publication volume since 2012, with the United States (1,675 publications) and China (1,310 publications) being the most productive countries. The Rizzoli Orthopaedic Institute, the Hospital for Special Surgery, and Rush University were identified as core research institutions, while Giuseppe Filardo was the most prolific author. Conclusion: This study provides bibliometric evidence that the research landscape of PRP for OA is transitioning from a focus on tissue regeneration to immunomodulation. The field has evolved from observing clinical outcomes to unraveling the intricate immune-mediated mechanisms, particularly the regulation of macrophage phenotypes and inflammatory mediators. Future research should prioritize standardizing PRP protocols based on their immunomodulatory potential and further exploring strategies to precisely manipulate the joint inflammatory environment for therapeutic gain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.