ArticleFrontiers in medicine2026
Case Report: Hypereosinophilic syndrome misdiagnosed as atopic dermatitis due to refractory pruritic rash masking peripheral neuropathy.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypereosinophilic syndrome (HES) is a rare and heterogeneous disorder characterized by persistent eosinophilia and multi-organ involvement. Cutaneous manifestations are common, whereas peripheral neuropathy may be underrecognized, particularly when dermatologic symptoms predominate. Case presentation: We report the case of a 49-year-old man with a 10-year history of recurrent pruritic papules initially managed as atopic dermatitis. Laboratory testing revealed marked eosinophilia (absolute eosinophil count: 5.29 × 10 Conclusion: This case highlights the importance of maintaining a high index of suspicion for systemic eosinophilic disorders in patients with chronic refractory pruritus and marked eosinophilia. Severe pruritus may obscure or delay recognition of concurrent neurological symptoms; therefore, early electrophysiological evaluation should be considered when systemic involvement is suspected. Targeted anti-IL-5 therapy represents an effective treatment strategy in selected cases of HES.
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