Evidence map›Paper›PMID 41958510›Full record

SynthesisJournal of medicine and life2026

Efficacy of androgen deprivation therapy (ADT) in combination with radiation therapy, compared to ADT alone in patients with high-risk prostate cancer: an updated systematic review and meta-analysis.

Walaa Borhan, Ahmad Assinnari, Abdulaziz Bakhsh, Mansour Alnazari, Emad Rajih

Abstract readSystematic ReviewMeta-AnalysisComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of medicine and life, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Walaa BorhanDepartment of Basic Medical Sciences, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Ahmad AssinnariDepartment of Basic Medical Sciences, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Abdulaziz BakhshDepartment of General and Specialized Surgery, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Mansour AlnazariDepartment of General and Specialized Surgery, College of Medicine, Taibah University, Madinah, Saudi Arabia.
Emad RajihDepartment of General and Specialized Surgery, College of Medicine, Taibah University, Madinah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgen deprivation therapy (ADT) has long been a cornerstone of treatment for patients with locally advanced or metastatic hormone-sensitive prostate cancer. The efficacy of ADT plus radiotherapy (RT) compared to ADT alone remains unclear due to conflicting results in existing literature. The study aimed to systematically evaluate the effectiveness of ADT combined with RT versus ADT alone in patients with prostate cancer (clinically node positive, locally advanced disease, metastatic disease), focusing on overall survival (OS), prostate-specific mortality (PSM), progression-free survival (PFS), and the risk of complications. A comprehensive search of PubMed, Embase, Web of Science, and Scopus was conducted between 1

Indexed as

Androgen AntagonistsProstatic NeoplasmsCombined Modality TherapyHumansMaleTreatment OutcomeAndrogen Antagonistsandrogen deprivationcomplicationslocally advancedmeta-analysisnode positiveprogressionprostate cancerradiotherapysurvivalsystematic review

Identifiers

PMID41958510
PMCPMC13059460

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.