Evidence map›Paper›PMID 41958483›Full record

ArticleChina CDC weekly2026

Genomic Insights into the 2024 HAdV-14p1 Strain in China: Traced to Early Prevalent Strains.

Yali Jin, Jiangxia Wang, Naiying Mao, Chunyu Zhu, Haiqing Zhou, Weiyan He, Hao Ding, Baicheng Xia, Aili Cui, Yan Zhang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in China CDC weekly, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yali JinNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Jiangxia WangDepartment of Infectious Diseases, Children's Hospital Affiliated to Chongqing Medical University, Chongqing, China.
Naiying MaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Chunyu ZhuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Haiqing ZhouNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Weiyan HeNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Hao DingNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Baicheng XiaNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Aili CuiNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Yan ZhangNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Zhen ZhuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Disease, NHC Key Laboratory of Medical Virology and Viral Diseases, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
Hongmei XuDepartment of Infectious Diseases, Children's Hospital Affiliated to Chongqing Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Human adenovirus type 14 variant p1 (HAdV-14p1) has been associated with severe respiratory infections worldwide. However, no cases of HAdV-14p1 infection have been reported in China since 2019. HAdV-14 was unexpectedly identified in 2024 in a pediatric patient hospitalized with bronchopneumonia in Chongqing, China. This study aims to elucidate the genetic characteristics of this strain and determine its phylogenetic relationship with previously circulating domestic and international strains. Methods: Whole-genome sequencing was performed on the HAdV-14 strain Chongqing2024-115, followed by comprehensive phylogenetic and genetic variation analyses using all publicly available global HAdV-14 genome sequences from the GenBank database. Results: Genome-based phylogenetic analysis classified global HAdV-14 strains into two well-supported clades: the HAdV-14 prototype clade and the variant HAdV-14p1 clade. The latter was further subdivided into three distinct subclades (I-III). Chongqing2024-115 clustered closely with earlier HAdV-14p1 subclade III and isolates from Beijing (2012) and Gansu (2013), showing high sequence identity (99.7%-99.9%). Compared with the genome of the HAdV-14 prototype strain (de Wit, AY803294), all three HAdV-14p1 subclades shared 99 specific nucleotide variations, including a six-nucleotide deletion in the knob domain of the fiber gene (nt751-756). The identification of subclade-specific variations and mutations unique to strain Chongqing2024-115 indicates ongoing microevolution within the HAdV-14p1 clade. Conclusions: Our results confirm that the contemporary HAdV-14p1 strain shares a common genetic ancestry with earlier Chinese subclade III strains. Considering the association between HAdV-14p1 and severe disease, sustained surveillance is essential to understand better its prevalence, evolution, and impact on public health in China.

Indexed as

BronchopneumoniaGenetic characteristicsHuman adenovirus type 14 variant p1

Identifiers

PMID41958483
PMCPMC13056505

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.