ReviewAndrology2026
Chromodomain Helicase DNA-Binding Proteins and Spermatogenesis: Current Advances.
Review in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
Funding
Abstract
backgroundMale infertility is a prevalent clinical condition, with approximately one-third of cases classified as idiopathic, frequently stemming from impaired spermatogenesis because of dysregulated gene expression. Chromodomain helicase DNA-binding (CHD) proteins are central chromatin remodelers that orchestrate this epigenetic regulation. For instance, smoking-induced hypermethylation of the CHD5 gene promoter is associated with impaired semen parameters.
objectiveThis review aims to summarize the roles and mechanisms of CHD proteins in spermatogenesis, explore their relationship with male infertility, and discuss their potential as diagnostic and therapeutic targets.
methodsA comprehensive literature review was conducted to synthesize current findings on the expression and function of CHD proteins across different stages of spermatogenesis.
resultsResearch has shown that CHD proteins are expressed in the testis and play crucial roles in multiple stages of spermatogenesis, from spermatogonial stem cell (SSC) maintenance to spermatid maturation, making them promising targets for understanding and treating male infertility.
conclusionCHD proteins represent important epigenetic regulators in spermatogenesis and may serve as valuable biomarkers or therapeutic targets for male infertility.
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