Evidence map›Paper›PMID 41958316›Full record

ArticleJournal of chemical information and modeling2026

Enzyme Reset: Water-Mediated Tautomerization Restores the Catalytic Asparagine in Protein

Òscar Vidal-Gironès, Enrico Trizio, Peilin Kang, Michele Parrinello, José Pablo Rivas-Fernández, Carme Rovira

Abstract read
In one paragraph

Article in Journal of chemical information and modeling, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Òscar Vidal-GironèsDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, Barcelona 08028, Spain.
Enrico TrizioAtomistic Simulations, Istituto Italiano di Tecnologia, Via Enrico Melen 83, Genoa 16142, Italy.ORCID 0000-0003-2042-0232
Peilin KangAtomistic Simulations, Istituto Italiano di Tecnologia, Via Enrico Melen 83, Genoa 16142, Italy.ORCID 0000-0003-2147-2472
Michele ParrinelloAtomistic Simulations, Istituto Italiano di Tecnologia, Via Enrico Melen 83, Genoa 16142, Italy.ORCID 0000-0001-6550-3272
José Pablo Rivas-FernándezDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, Barcelona 08028, Spain.ORCID 0000-0002-1349-3049
Carme RoviraDepartament de Química Inorgànica i Orgànica (Secció de Química Orgànica) and Institut de Química Teòrica i Computacional (IQTCUB), Universitat de Barcelona, Martí i Franquès 1, Barcelona 08028, Spain.ORCID 0000-0003-1477-5010

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein

Indexed as

AsparagineBiocatalysisFucosyltransferasesWaterCatalytic DomainIsomerismMolecular Dynamics SimulationQuantum MechanicsQuantum TheoryAsparagineFucosyltransferasesWater

Identifiers

PMID41958316
PMCPMC13213826

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.