Evidence map›Paper›PMID 41958239›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2026

Real-Time Detection of Burn Wound Infection via a Turn-On NIR-II Fluorescent Probe.

Kang Lu, Shudan Yang, Meggie Wang, Mengxi Zhang, Boyang Zhou, Kaiqiang Yang, Natalia V Kirienko, Han Xiao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kang LuDepartment of Chemistry, Rice University, Houston, Texas, USA.
Shudan YangDepartment of Chemistry, Rice University, Houston, Texas, USA.
Meggie WangDepartment of Biosciences, Rice University, Houston, Texas, USA.
Mengxi ZhangDepartment of Chemistry, Rice University, Houston, Texas, USA.
Boyang ZhouDepartment of Chemistry, Rice University, Houston, Texas, USA.
Kaiqiang YangDepartment of Chemistry, Rice University, Houston, Texas, USA.
Natalia V KirienkoDepartment of Biosciences, Rice University, Houston, Texas, USA.
Han XiaoDepartment of Chemistry, Rice University, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-4311-971X

Funding

Engineering Proteins with Noncanonical Amino AcidsR35GM133706 · NIGMS · RICE UNIVERSITY · PI Han Xiao · 2019 to 2026
$2.9M
Molecular Basis of Infectious Diseases Training GrantT32AI055449 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LORENZ, MICHAEL C · 2005 to 2025
$2.6M
Modulation of Epigenetic Target in the Bone to Treat Breast Cancer MetastasisR01CA277838 · NCI · RICE UNIVERSITY · PI Han Xiao, Xiang Zhang · 2023 to 2026
$2.6M
Molecular mechanisms for clinical dominance of P. aeruginosa ST111 isolatesR21AI176089 · NIAID · RICE UNIVERSITY · PI KIRIENKO, NATASHA · 2024 to 2025
$414k
Hevolution Foundation HF-GRO-23-1199140-47Medical Research Award from Robert J. Kleberg, Jr. and Helen C. Kleberg FoundationNCI NIH HHS R01 CA277838NIAID NIH HHS R21 AI176089NIAID NIH HHS T32 AI055449NIGMS NIH HHS R35 GM133706NIH HHS R01CA277838NIH HHS R21AI176089NIH HHS R35GM133706NIH HHS T32AI055449the Advanced Research Projects Agency for Health 1AY2AX000081the Robert A. Welch Foundation C-1970the US Department of Defense HT9425-23-1-0494the US Department of Defense T9425-23-1-0494
6 · The paper itself

Abstract

Skin infections represent a major clinical challenge and are frequently associated with persistent bacterial colonization and delayed wound healing. The progression of these skin infections, particularly in burn wounds, is directly mirrored by an elevation in local pH, which serves as a critical physicochemical marker of bacterial metabolic activity. However, studies using pH as a biomarker for real-time, in situ monitoring of infection status remain relatively limited. Current pH-responsive probes are often restricted by shallow tissue penetration and significant background interference, which reduce sensitivity and imaging contrast in complex biological environments. Herein, using a difluoroboron (BF

Indexed as

Boron CompoundsBurnsFluorescent DyesWound InfectionAnimalsFluorescent Chemosensor CompoundsHumansHydrogen-Ion ConcentrationOptical ImagingBoron CompoundsFluorescent Chemosensor CompoundsFluorescent Dyesbacterial infectionburn wounddifluoroboron (BF2) formazanateNIR‐II bioimagingpH imaging

Identifiers

PMID41958239
PMCPMC13138872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.