ArticleImmunity, inflammation and disease2026
Relationship Between IL6/IL10 Serum Concentrations and Organ Function in Critically Ill Patients Based on Sepsis: A Prospective Study.
Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Bridging sepsis physiology and biosensor engineering: a clinical perspective on electrochemical cytokine sensor design.Frontiers in bioengineering and biotechnology · 2026Article
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5 authors.
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Abstract
backgroundCritical illnesses, particularly sepsis with accompanying organ dysfunction, significantly increase patient mortality. The imbalance between pro-inflammatory and anti-inflammatory responses is closely linked to the onset and progression of organ dysfunction in critical conditions. The ratio of interleukin-6 (IL6) to interleukin-10 (IL10) is a useful indicator of the pro- and anti-inflammatory status. PURPOSE: To investigate the correlation between IL6/IL10 and various outcomes, including organ function, in critically ill patients.
methodsThis prospective study was conducted from 1 January to 31 May 2023 at Peking Union Medical College Hospital. Baseline characteristics, intensive care unit (ICU) parameters, laboratory test results, and outcome data were extracted from the electronic medical records system. Correlations between IL6/IL10 and various outcomes, including organ function, were analyzed.
resultIn total, 208 patients were included in the study. Higher IL6/IL10 levels were associated with shorter in-hospital stay, ICU stay, and mechanical ventilation time in both univariate and multivariate models. The β values and 95% confidence intervals in the multivariate model were -0.526 (- 0.684, -0.369), -0.183 (- 0.245, -0.121), and -1.510 (- 2.565, -0.456), respectively. Significant positive associations between IL6/IL10 and all organ functions except the platelet count and PaO
conclusionOur study showed that in critically ill patients, particularly those with sepsis, IL6/IL10 is significantly associated with outcomes such as organ dysfunction (including coagulation, renal, cardiac, and pulmonary function). These findings are hypothesis-generating, suggesting that IL6/IL10 may serve as a valuable indicator associated with inflammation and severity changes in critical illness.
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