ArticleJournal of agricultural and food chemistry2026
10-Hydroxy-2-decenoic Acid Attenuates Colitis-Associated Cognitive Dysfunction via IFITM3-Related Gut-Brain Axis Inflammation.
Article in Journal of agricultural and food chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- The potential connection between inflammatory bowel disease and Alzheimer's disease: mechanistic insights and therapeutic implications.Frontiers in immunology · 2026Review
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6 authors.
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Abstract
10-Hydroxy-2-decenoic acid (10-HDA), a bioactive compound in royal jelly, has anti-inflammatory and antioxidant properties. This study investigates whether 10-HDA alleviates cognitive impairment caused by dextran sulfate sodium (DSS)-induced chronic colitis, focusing on IFITM3, an immune regulator linked to intestinal and neuroinflammation. DSS treatment increased IFITM3 in the colon and hippocampus, resulting in neuroinflammation and cognitive deficits. 10-HDA reduced colonic inflammation, suppressed IFITM3-mediated NF-κB activation, improved cognitive performance, and attenuated astrocyte reactivity. IFITM3 knockout mice showed less colitis and neuroinflammation, and 10-HDA's effects were diminished in these mice, suggesting an IFITM3-related mechanism. These results suggest 10-HDA as a potential dietary agent for gut-brain axis health in chronic inflammation.
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