Evidence map›Paper›PMID 41957806›Full record

ArticleLipids in health and disease2026

Joint associations of grip strength, lipid levels, and lipid-related genetic risk with atrial fibrillation.

Zihao Zhang, Jianfeng Huang, Xu Wang, Qing Li, Yirong Yang, Kuan Ning, Yifan Wang, Tanxiu Chen, Rui Xiong, Xinjie Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lipids in health and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zihao Zhang *Institute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Jianfeng Huang *Department of Ultrasound Diagnosis, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Xu Wang *Institute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Qing LiInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Yirong YangInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Kuan NingInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Yifan WangInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Tanxiu ChenInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Rui XiongInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Xinjie LiuInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Shaolie HuangDepartment of Cardiovascular Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Lijuan DengDepartment of Nephrology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China.
Pingping ShenDepartment of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, 130000, Jilin Province, China.
Yian ZhanRespiratory and Critical Care Medicine, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330200, Jiangxi Province, China.
Shanhua XiaoDepartment of Nephrology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi Province, China. ndyfy02762@ncu.edu.cn.
Wen-Quan ZouInstitute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, 330200, Jiangxi Province, China. wenquanzou@ncu.edu.cn.

Funding

Jiangxi Key Laboratory of Neurological Diseases 2024SSY06072National Natural Science Foundation 82471499startup package and developmental funds of the First Affiliated Hospital of Nanchang University #500021001, #500021002
6 · The paper itself

Abstract

introductionThe associations between lipid levels and atrial fibrillation (AF) remain inconsistent, and whether functional status modifies these relationships is unclear. In this prospective cohort study, the joint associations of grip strength, lipid levels, and lipid-related genetic risk with incident AF were evaluated.

methodsA prospective cohort analysis was conducted, and Cox models were used to evaluate the associations of lipid levels, lipid-related polygenic risk scores (PRSs), and grip strength with incident AF. Joint exposure categories were constructed according to lipid status (normal vs. elevated) and grip strength level (normal vs. reduced) to compare AF risk across different combinations. Age-stratified analyses were further conducted to examine age-related heterogeneity. Interaction terms between lipid levels and grip strength were included to test interaction and assess the effect modification of grip strength on the lipid-AF association. Participants receiving lipid-lowering therapy at baseline were excluded in sensitivity analyses.

resultsLipid levels, lipid-related PRSs, and grip strength were each associated with incident AF. In joint exposure analyses, individuals with both elevated lipid levels and reduced grip strength had a lower risk of AF than those with elevated lipids but normal grip strength in the overall population [HR 0.925 (0.889, 0.961)]. However, among participants younger than 55 years, the coexistence of elevated lipids and reduced grip strength was associated with a higher risk compared with having either abnormality alone. Interaction analyses demonstrated significant relations between low-density lipoprotein (LDL) levels, LDL-PRS, and grip strength, indicating that the latter significantly modified the association between lipids and AF. When grip strength was below 41.53 kg for LDL, below 48.90 kg for total cholesterol, and within 17.07–36.11 kg for triglycerides, elevated lipid levels were linked to a reduced risk of AF; this association gradually attenuated and became non-significant as grip strength increased.

conclusionsThis study found that grip strength significantly modified the associations of lipid levels and lipid-related genetic risk with AF, with evident age-related heterogeneity. In individuals younger than 55 years, effective lipid management and improving muscle strength may help reduce the risk of AF.

Indexed as

Atrial FibrillationHand StrengthLipidsAgedFemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedProspective StudiesRisk FactorsTriglyceridesLipidsTriglyceridesAtrial FibrillationCholesterolMuscle StrengthTriglycerides

Identifiers

PMID41957806
PMCPMC13188619

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.