Evidence map›Paper›PMID 41957668›Full record

ArticleGenome biology2026

Allelic structural variation at the NLR25-1 locus enhances defense against Pseudomonas syringae in kiwifruit.

Ying Wu, Yingzhen Wang, Yunzhi Lin, Meng Zhao, Yuyu Huo, Tao Zhang, Hongtao Wang, Yanyan Zhu, Lihuan Wang, Pengpeng Zheng and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ying Wu *Anhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Yingzhen Wang *School of Forestry Science and Technology, Lishui Vocational and Technical College, Lishui, 323000, China.
Yunzhi Lin *Anhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Meng ZhaoAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Yuyu HuoAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Tao ZhangAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Hongtao WangAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Yanyan ZhuAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Lihuan WangAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Pengpeng ZhengAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China.
Junyang YueAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China. yuejy@ahau.edu.cn.
Songhu WangAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China. wangsonghu@ahau.edu.cn.
Yongsheng LiuAnhui Province Key Laboratory of Horticultural Crop Quality Biology, School of Horticulture, Anhui Agricultural University, Hefei, 230036, China. liuyongsheng1122@ahau.edu.cn.

Funding

Lishui City's Key R&D Program Project 2025zdyf14National Natural Science Foundation of China 32472680
6 · The paper itself

Abstract

backgroundCanker disease caused by Pseudomonas syringae pv. actinidiae (Psa) poses a major threat to cultivated kiwifruit, and utilization of wild relatives are key to improve resistance. However, comprehensive comparative genomic analyses between cultivated kiwifruit and their wild relatives with enhanced resistance to Psa remain limited.

resultsHere we generate chromosome-scale genome assemblies for eleven wild Actinidia eriantha accessions and one interspecific hybrid between Actinidia eriantha and cultivated Actinidia chinensis var. chinensis. Integrating these with twelve previously released genomes including three Actinidia eriantha and nine Actinidia chinensis var. chinensis, we construct a reference-unbiased graph-based pangenome. These datasets reveal extensive genomic variation, including 31,790,044 SNPs, 13,512,079 InDels and 623,478 structural variations, and provide a landscape of structural variations within and between the two species. Leveraging these datasets, we identify a wild allele showing allele-specific expression, AeNLR25-1, which enhances Psa resistance in cultivated kiwifruit. Genetic and molecular analyses demonstrate that a transposable element-induced structural variation in the AeNLR25-1 promoter introduces a species-specific WRKY binding site, conferring enhanced defense against Psa.

conclusionsPangenome across cultivated species and wild relatives provides a theoretical framework for accelerating kiwifruit genetic improvement through pangenome-enabled identification of favorable wild alleles.

Indexed as

ActinidiaAllelesDisease ResistancePlant DiseasesPlant ProteinsPseudomonas syringaeDNA Transposable ElementsGenome, PlantPolymorphism, Single NucleotideDNA Transposable ElementsPlant ProteinsActinidiaAllele-specific expression (ASE)PangenomePseudomonas syringae pv. actinidiae (Psa)Structural variation (SV)

Identifiers

PMID41957668
PMCPMC13173888

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.