ArticleOrphanet journal of rare diseases2026
Higher educational attainment in Huntington disease families: evidence from the Enroll-HD study.
Article in Orphanet journal of rare diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundHuntington disease (HD) is an inherited neurodegenerative disorder that impairs motor, cognitive, and psychiatric function. Offspring of individuals with HD may experience early caregiving responsibilities, potentially disrupting their educational outcomes. We evaluated the associations between parental age at HD symptom onset, genetic-expansion, sociodemographic, and regional factors with offspring educational attainment outcomes in adulthood.
methodsWe estimated odds ratios using logistic regression to evaluate associations between higher educational attainment in offspring and parental age at symptom onset, genetic-expansion, race, and region among adults ([Formula: see text]18 years) in the Enroll-HD study. To assess the relative importance of exposures in predicting educational outcomes, we fit a random forest model and ranked these based on mean decrease in accuracy.
resultsIn our explorative analysis, participants whose parents had an earlier age at HD symptom onset were associated with lower odds of attaining a higher education. We also identified a nonlinear, inverted-U association between genetic-expansion and the probability of higher educational attainment–a pattern that has been observed in prior studies of neurocognitive function in children. Marked differences were also observed by race and region: Black, Hispanic/Latino, and Native American participants were associated with lower odds of higher education compared with White participants, and those residing outside Northern America were associated with lower odds of higher educational attainment. DISCUSSION: Earlier parental HD onset was associated with lower educational attainment in offspring and disparities were observed across genetic-expansion, sociodemographic, and regional groups. Our exploratory findings may inform future studies aimed at better understanding educational inequities among families affected by HD and related neurodegenerative disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.