Evidence map›Paper›PMID 41957610›Full record

ArticleGut pathogens2026

Association of Helicobacter pylori with Candida albicans enhances fungal virulence and stress tolerance.

Jianchao Sun, Qing Luo, Tingxiu Yang, Xiaoli Xu, Tingting Luo, Huifeng Jian, Xianli Chen, Guzhen Cui, Zhenghong Chen

Abstract read
In one paragraph

Article in Gut pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Ergosterol from Yeasts PromotesInternational journal of molecular sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jianchao SunGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, School of Basic Medical Science, Guizhou Medical University, Guiyang, China.
Qing LuoThe Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, China.
Tingxiu YangDepartment of Hospital Infection and Management, Guizhou Province People's Hospital, Guiyang, China.
Xiaoli XuGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, School of Basic Medical Science, Guizhou Medical University, Guiyang, China.
Tingting LuoGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, School of Basic Medical Science, Guizhou Medical University, Guiyang, China.
Huifeng JianGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, School of Basic Medical Science, Guizhou Medical University, Guiyang, China.
Xianli ChenGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, School of Basic Medical Science, Guizhou Medical University, Guiyang, China.
Guzhen CuiGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, School of Basic Medical Science, Guizhou Medical University, Guiyang, China.
Zhenghong ChenGuizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, School of Basic Medical Science, Guizhou Medical University, Guiyang, China. chenzhenghong@gmc.edu.cn.

Funding

Guizhou Key Laboratory of Microbio and Infectious Disease Prevention & Control, China ZDSYS[2023]004the 111 Project D20009the Central-Guided Local Science and Technology Projects of Guizhou Province, China Qiankehe [2025] 024the Marshall Joint Laboratory Fund of Affiliated Hospital of Guizhou Medical University GYFYMF001, GYFYMF002the Natural Science Foundation of China 82260402the Science and Technology Fund Project of the Guizhou Health Commission GZWKJ 2022-521
6 · The paper itself

Abstract

backgroundBacterial associations with fungal hosts are increasingly recognized as common rather than exceptional. Among these interactions, Candida spp. and Helicobacter pylori are of particular interest, as evidence suggests that Candida may serve as a potential host for H. pylori, facilitating its persistence and dissemination. Although interactions between Candida spp. and members of the bacterial microbiota-particularly H. pylori-are increasingly recognized for their role in modulating microbial ecology and influencing pathological outcomes in the host, the impact of H. pylori on Candida albicans remains poorly characterized. Whether this interaction alters the biological behavior or pathogenic potential of Candida spp. remains poorly understood. In this study, C. albicans strains CacoHp, which were detected to be positive for H. pylori-specific genes, were generated through co-culture, and the effects of this bacterial-fungal interaction on tolerance and virulence were investigated.

resultsCo-culture with H. pylori S7 and C. albicans SC5314 yielded Hp-positive C. albicans CacoHp. Compared with the parental strain SC5314, CacoHp exhibited increased tolerance to antifungal agents, sodium dodecyl sulfate, and H

conclusionsCo-culture with H. pylori generates C. albicans strains CacoHp, which were detected to be positive for H. pylori-specific genes, that exhibit enhanced chemical stress tolerance and increased virulence. This study first revealed the influence of H. pylori on Candida phenotypes, further supporting the clinical relevance of their interaction.

Indexed as

Candida albicansdrug toleranceHelicobacter pylorimicrobial interactionvirulence

Identifiers

PMID41957610
PMCPMC13220638

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.