Evidence map›Paper›PMID 41957541›Full record

ArticleChemMedChem2026

Coordination of Anle138b to Silver Results in Selective Reduction of a C-Terminal Truncated α-Synuclein Protein and Increased Aggregate Size.

Kelly L Rue, Susana Herrera, Zhi-Chun Shi, Indranil Chakraborty, Jeremy Tachiki, Josue Ballesteros, Julie K Andersen, Gordon J Lithgow, Wisam A Al Isawi, Gellert Mezei and 2 more

Abstract read
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In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Kelly L RueDepartment of Chemistry & Biochemistry and the Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA.
Susana HerreraDepartment of Chemistry & Biochemistry and the Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA.
Zhi-Chun ShiDepartment of Chemistry & Biochemistry and the Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA.
Indranil ChakrabortyDepartment of Chemistry & Biochemistry and the Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA.
Jeremy TachikiBuck Institute for Research on Aging, Novato, California, USA.
Josue BallesterosBuck Institute for Research on Aging, Novato, California, USA.
Julie K AndersenBuck Institute for Research on Aging, Novato, California, USA.
Gordon J LithgowBuck Institute for Research on Aging, Novato, California, USA.
Wisam A Al IsawiDepartment of Chemistry, Western Michigan University, Kalamazoo, Michigan, USA.
Gellert MezeiDepartment of Chemistry, Western Michigan University, Kalamazoo, Michigan, USA.ORCID https://orcid.org/0000-0002-3120-3084
Minna SchmidtBuck Institute for Research on Aging, Novato, California, USA.ORCID https://orcid.org/0000-0003-2321-2324
Raphael G RaptisDepartment of Chemistry & Biochemistry and the Biomolecular Sciences Institute, Florida International University, Miami, Florida, USA.ORCID https://orcid.org/0000-0002-9522-0369

Funding

Training in Basic Research on Aging and Age-Related DiseaseT32AG000266 · NIA · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Lisa M Ellerby · 1998 to 2026
$13.8M
NIA NIH HHS T32 AG000266
6 · The paper itself

Abstract

Parkinson's disease (PD) is a prevalent age-related neurodegenerative syndrome, partially thought to be caused by a decrease in α-synuclein proteostasis. Anle138b = 5-(1,3-benzodioxol-5-yl)-3-(3-bromophenyl)-1H-pyrazole (HL) is undergoing clinical trials as a promising mitigator of α-synuclein aggregation. Because complexation to metals is known to modulate the activity of several drugs, we have prepared and characterized: H

Indexed as

alpha-SynucleinCoordination ComplexesPyrazolesSilverBenzodioxolesHumansProtein Aggregates3-(1,3-benzodioxol-5-yl)-5-(3-bromophenyl)-1H-pyrazolealpha-SynucleinBenzodioxolesCoordination ComplexesProtein AggregatesPyrazolesSilverconfocal microscopyEdman sequencingParkinson's diseaseX‐ray crystallographyα‐synuclein

Identifiers

PMID41957541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.