Evidence map›Paper›PMID 41957415›Full record

ArticleScientific reports2026

Controlled heating between 100 and 500 degrees celsius improves enamel resistance to erosion in vitro.

Richard J Wierichs, Seyed Ahmad Banihashem Rad, Joel Glöckler, Marin D Bilandzic, Stephanie A Garofalo, Gabriella T Schrotter, Samira H Niemeyer, Guglielmo Campus, Hendrik Meyer-Lueckel, Marcella Esteves-Oliveira

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Richard J Wierichs *Department of Operative Dentistry and Periodontology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Seyed Ahmad Banihashem Rad *Department of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY, USA.
Joel GlöcklerDepartment of Conservative Dentistry, Periodontology and Endodontology, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
Marin D BilandzicInstitute of Mineral Engineering (GHI), Chair of Glass and Glass-Ceramic, RWTH Aachen University, Aachen, Germany.
Stephanie A GarofaloDepartment of Conservative Dentistry, Periodontology and Endodontology, Faculty of Medicine, University of Tübingen, Tübingen, Germany.
Gabriella T SchrotterDepartment of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Samira H NiemeyerDepartment of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland.
Guglielmo CampusDepartment of Cariology, Institute of Odontology, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden.
Hendrik Meyer-LueckelDepartment of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland.
Marcella Esteves-OliveiraDepartment of Conservative Dentistry, Periodontology and Endodontology, Faculty of Medicine, University of Tübingen, Tübingen, Germany. Marcella.Esteves@med.uni-tuebingen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the effect of controlled heating at different temperatures on enamel erosion resistance, One hundred and twelve polished bovine enamel samples were randomly allocated to one of seven groups (n = 16): no treatment (negative control [C]); daily application of fluoride solution (500 ppm F-, 800 ppm Sn2+ as AmF/NaF/SnCl2, pH4.5, standard control [F]); and five oven-heated groups (100 °C, 200 °C, 300 °C, 400 °C, 500 °C). Heating in a dental oven was conducted atrates of 1 K/min, and each temperature level was maintained for 1 min. After surface treatment, all samples underwent a six-day erosive cycling protocol, with six daily immersions in citric acid (0.05 M, pH 2.3, 2 min) and storage in remineralization solution (≥ 1 h) between cycles. Enamel surface loss (µm) was measured at baseline and every second day (D2, D4, D6) using a 3D-laser-profilometer. Data were analyzed with two-way repeated measures ANOVA and post-hoc comparisons (p < 0.05). All heated groups (100–500 °C) and F significantly increased enamel erosion resistance compared to C (−24.6 ± 1.3 µm,p < 0.05). Furthermore, heating at 300 °C (−8.3 ± 2.7 µm), 400 °C (-5.6 ± 2.4 µm) and 500 °C (−3.2 ± 2.4 µm) resulted in significantly greater erosion resistance than F (−12.3 ± 2.3 µm, p = 0.02/ < 0.01), with 400 °C and 500 °C reducing enamel surface loss by 77 and 87%, respectively. Controlled heating significantly increased enamel erosion resistance, with 400 °C and 500 °C showing the highest protection. While oven heating is not clinically applicable, these findings contribute to understanding of CO₂ laser-induced erosion resistance. The significant increase in enamel erosion resistance following controlled heating suggests that structural modifications play a key role in erosion prevention. While oven heating provided standardized conditions, future research should explore whether similar protective effects can be achieved with clinically applicable CO₂-laser parameters to optimize non-invasive strategies for enamel preservation.

Indexed as

Dental EnamelHot TemperatureTooth ErosionAnimalsCattleFluoridesFluoride TreatmentFluoridesDemineralizationEnamelErosive tooth wearFluorideLaserOvenPreventionTinWear

Identifiers

PMID41957415
PMCPMC13069023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.