Articlenpj aging2026
Plasma hippuric acid as a marker of frailty influenced by dietary fruit and vegetable consumption: longitudinal analysis in Italian cohorts of older adults.
Article in npj aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
16 authors.
Funding
Abstract
Frailty is a geriatric syndrome characterised by loss of function and increased risk of death. Identification of individuals at risk of frailty is crucial for effective preventive interventions. This study aimed to investigate the association between plasma hippuric acid concentrations and frailty across two longitudinal Italian cohorts. Plasma hippuric acid was quantified using European Medicines Agency-validated mass spectrometry methods in plasma samples from InCHIANTI (n = 534; 55.4% females; aged ≥65 years, 1998, 2002, 2004, 2008 follow-ups, FU) and InveCe.Ab (n = 912; 53.8% females; aged ≥70 years, 2010, 2012, 2014, 2018 FU) participants who were non-frail at baseline. Frailty was defined through two different classifications: frailty index (FI) and frailty phenotype (FP). Longitudinal association between hippuric acid and frailty indexes within the two cohorts was assessed by linear mixed models adjusting for sex, age, educational status, renal and liver function, and body mass index. Mediation analyses explored the role of hippuric acid in mediating the fruit and vegetable consumption-frailty relationship. Median values of hippuric acid concentrations were significantly lower in frail compared to non-frail participants (measured by FI) in both (i) InCHIANTI study: non-frail = 1.59 (Q
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