Evidence map›Paper›PMID 41957361›Full record

ArticleNature communications2026

CD73

Yuzi Tian, Jia Guo, Jinjian Sun, Xiaoye Zhang, Guowei Zhou, Lin Ye, Yan Zhang, Peihua Liu, Junyu Zhou, Chengeng Xiao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuzi Tian *Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jia Guo *Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jinjian SunNational Clinical Research Center for Geriatric Disease, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiaoye ZhangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Guowei ZhouDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Lin YeDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yan ZhangFuRong Laboratory, Changsha, Hunan, China.
Peihua LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Junyu ZhouDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Chengeng XiaoDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Xiaoyun XieDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang XiaNational Medical Metabolomics International Collaborative Research Center, Central South University, Changsha, Hunan, China.ORCID http://orcid.org/0000-0002-8059-6179
Hervé BachelezDepartment of Dermatology, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris Laboratory of Genetic of Skin Diseases, INSERM U1163, Imagine Institute for Human Genetic Diseases, Paris Cité University, Paris, France.
Hong LiuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Hongliu1014@csu.edu.cn.ORCID http://orcid.org/0000-0001-9976-2985
Xiang ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan, China. chenxiangck@126.com.ORCID http://orcid.org/0000-0001-8187-636X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic dysregulation within the epithelial immune microenvironment (EIME) drives chronic inflammatory skin diseases like psoriasis, but the immune mechanisms and downstream consequences remain unclear. Here we perform in-depth metabolomic analysis showing that nucleotide metabolism is enhanced in psoriatic patients, with elevated adenosine levels closely correlating with disease severity. Single-cell and spatial transcriptomics analyses revealed that adenosine is primarily generated from a population of CD73

Indexed as

5'-NucleotidaseFibroblastsKeratinocytesPsoriasisAdenosineAnimalsCellular MicroenvironmentDisease Models, AnimalFemaleGPI-Linked ProteinsHumansImiquimodInflammationMaleMiceMice, Inbred C57BL5'-NucleotidaseAdenosineGPI-Linked ProteinsImiquimodNT5E protein, humanReceptor, Adenosine A2B

Identifiers

PMID41957361
PMCPMC13389033

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.