Evidence map›Paper›PMID 41957335›Full record

ArticleEuropean geriatric medicine2026

A three-biomarker panel for frailty prediction and risk stratification in institutionalized older adults: a multicenter validation study.

Amr Ali Mohamed Abdelgawwad El-Sehrawy, Ismail Abdelhameed Abadia Ali Kandi, Mansuor A Alanazi, Saud S Alharbi, Sultan Mohammed Alanazi, Mona Y Alqassim, Amal A Abdulbaqi, Amro Elbaz

Abstract readMulticenter StudyValidation Study
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In one paragraph

Article in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Amr Ali Mohamed Abdelgawwad El-SehrawyDepartment of Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt. sehrawyamr@gmail.com.ORCID http://orcid.org/0009-0007-1925-7227
Ismail Abdelhameed Abadia Ali KandiDepartment of Internal Medicine, Mansoura University, Mansoura, Egypt.
Mansuor A AlanaziDepartment of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Saud S AlharbiDepartment of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Sultan Mohammed AlanaziDepartment of Medical Laboratory Technology, College of Applied Medical Sciences, Northern Border University, Arar, Saudi Arabia.
Mona Y AlqassimDepartment of Technology, Applied College, Taif University, Taif, Saudi Arabia.
Amal A AbdulbaqiDepartment of Biology, University College in Darb, Jazan University, P.O. Box. 114, Jazan 45142, Saudi Arabia.
Amro ElbazFaculty of Medicine, Mansoura University, Mansoura, Egypt. dramrbaz@mans.edu.eg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFrailty affects between 20 and 75% of residents in long-term care facilities; however, there is a notable absence of objective biological assessment tools for proactive risk stratification.

methodsTo address this gap, we examined inflammatory and metabolic biomarkers using a validated 52-item Frailty Index in a cohort of 292 older adults residing in institutions. Each participant completed an assessment of the Frailty Index and underwent quantification of 12 inflammatory and metabolic-nutritional biomarkers that encompass the pathways of inflammation, proteostasis, and metabolic dysregulation.

resultsIn a study of 292 institutionalized older adults (mean age 82.6 ± 6.7 years, 68.8% female, 58.6% frail), a simplified three-biomarker panel-interleukin-6 (IL-6), prealbumin, and high-sensitivity C-reactive protein (hs-CRP)-demonstrated excellent predictive accuracy. A simplified three-biomarker panel-interleukin-6 (IL-6), prealbumin, and high-sensitivity C-reactive protein (hs-CRP)achieved excellent diagnostic accuracy (area under curve (AUC) = 0.861, 95% confidence interval (CI) 0.801-0.915), with 81.2% sensitivity and 85.4% specificity for This parsimonious panel retained 96.5% of the predictive performance of the full 12-biomarker model while using only routinely available laboratory tests.

conclusionTaken together, these results underscore the potential of inflammatory and metabolic biomarkers for the early identification of high-risk residents, thereby supporting personalized nursing care. Integrating biomarker-guided stratification may facilitate the targeted allocation of nutritional support, physical therapy, and inflammatory management, potentially preventing 30-40% of frailty progression.

Indexed as

C-Reactive ProteinFrail ElderlyFrailtyGeriatric AssessmentInterleukin-6PrealbuminAgedAged, 80 and overBiomarkersFemaleHumansMaleNursing Home ResidentsRisk AssessmentBiomarkersC-Reactive ProteinInterleukin-6PrealbuminBiomarkersFrailtyGeriatric nursingInflammationLong-term carePredictive models

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PMID41957335

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