ArticleScientific reports2026
A novel prognostic biomarker for colorectal cancer: the ratio of red cell distribution width to lymphocytes.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Our previous study revealed that an elevated ratio of red cell distribution width to lymphocyte ratio (RLR) might be linked to unfavorable poorer outcomes among colorectal cancer (CRC) patients. Nevertheless, additional research is necessary to authenticate these findings and ascertain the clinical relevance of RLR in the context of CRC. A total of 1,541 patients diagnosed with CRC were retrospectively included in this study. The association between clinical-pathological data and overall survival (OS) was examined using Kaplan-Meier curves. A machine learning approach was employed to identify prognostic indicators, construct a risk model, determine independent factors influencing OS, and assess the model’s accuracy. In CRC patients, RLR exhibited the highest average area under the curve, sensitivity, and specificity, as well, as the highest youden, except for CEA. Subsequently, the three indicators, preoca199, preoCEA, and preoca125, were normalized for CRC patients. Using the weight matrix in the SVM classification model, the 24 indicators were ranked, identifying the top 5 important indicators. The final models included CEA (HR = 1.0032, P = 0.0025), RLR (HR = 1.018, P = 0.0157), T-stage (HR = 1.4456, P < 0.001), N-stage (HR = 1.2092, P = 0.0962), and Stage (HR = 1.7024, P = 0.0012). Notably, OS was significantly prolonged in the group with low levels of CEA and low RLR. RLR could be a novel prognostic marker for OS in patients with CRC.
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