Evidence map›Paper›PMID 41957185›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Regulatory patterns of antibody-dependent cellular phagocytosis-related genes in triple-negative breast cancer: An integrated multi-omics and single-cell analysis.

Guihua Hong, Zhanyue Cui, Xiaowen Xu, Shiwei Lin, Changqing Yang, Ran Ding, Ludan Liang, Ying Chen, Ziyue Tian

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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Guihua HongHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, No. 19, Xiuhua Road, Xiuying District, Haikou City, Hainan Province, 570311, China.
Zhanyue CuiHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, No. 19, Xiuhua Road, Xiuying District, Haikou City, Hainan Province, 570311, China.
Xiaowen XuHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, No. 19, Xiuhua Road, Xiuying District, Haikou City, Hainan Province, 570311, China.
Shiwei LinHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, No. 19, Xiuhua Road, Xiuying District, Haikou City, Hainan Province, 570311, China.
Changqing YangHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, No. 19, Xiuhua Road, Xiuying District, Haikou City, Hainan Province, 570311, China.
Ran DingSouth China University of Technology, Guangzhou International Campus, Guangzhou, 511442, Guangdong, China.
Ludan LiangSouth China University of Technology, Guangzhou International Campus, Guangzhou, 511442, Guangdong, China.
Ying ChenThe First Affiliated Hospital to Changchun University of Chinese Medicine, 1478 Gongnong Road, Chaoyang District, ChangchunJilin, 130021, No., China.
Ziyue TianHainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Hainan Province, Haikou, No. 19, Xiuhua Road, Xiuying District, Haikou City, Hainan Province, 570311, China. tianziyue1013@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) remains a therapeutic challenge due to aggressive biology and limited targeted therapies. While antibody-dependent cellular phagocytosis (ADCP) offers potential for immune intervention, its molecular drivers and clinical implications in TNBC are poorly defined. Multi-omics analysis of TNBC specimens (TCGA, METABRIC, GEO) integrated differential expression, protein-protein interactions, single-cell RNA sequencing (scRNA-seq), and drug sensitivity profiling. Prognostic models were validated across three cohorts. We identified six core ADCP regulators (MUC1, PTEN, BCL6, CD19, LCK, CD79B) defining a high-risk subgroup with elevated metastasis risk and reduced 5-year DFS. scRNA-seq revealed subtype-specific expression patterns across 100,064 cells, linking MUC1/BCL6 to macrophage phagocytosis suppression. A prognostic nomogram integrating these genes achieved superior accuracy versus clinical staging, validated externally. High-risk tumors exhibited PARP inhibitor sensitivity but CDK4/6 inhibitor resistance. This study establishes ADCP-related genes as dual biomarkers for TNBC risk stratification and therapy selection, revealing actionable vulnerabilities for precision phagocytosis modulation.

Indexed as

PhagocytosisTriple Negative Breast NeoplasmsBiomarkers, TumorFemaleGene Expression Regulation, NeoplasticHumansLymphocyte Specific Protein Tyrosine Kinase p56(lck)Mucin-1MultiomicsPrognosisProto-Oncogene Proteins c-bcl-6PTEN PhosphohydrolaseSingle-Cell AnalysisBiomarkers, TumorLCK protein, humanLymphocyte Specific Protein Tyrosine Kinase p56(lck)MUC1 protein, humanMucin-1Proto-Oncogene Proteins c-bcl-6PTEN PhosphohydrolaseAntibody-dependent cellular phagocytosisImmunobiologyPrognosticSubtypesTriple-negative breast cancer

Identifiers

PMID41957185

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.