Evidence map›Paper›PMID 41957119›Full record

ArticleEMBO molecular medicine2026

Impaired vitamin D signaling reveals neutrophils as key drivers of prostate cancer dissemination.

Kateryna Len-Tayon, Justine Gantzer, Charles Dariane, Olivier Fogel, Vanessa Friedrich, Daniela Rovito, Véronique Lindner, Valentine Gilbart, Darya Yanushko, Sandrine Henri and 2 more

Abstract read
In one paragraph

Article in EMBO molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kateryna Len-TayonInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France.ORCID 0000-0002-5397-391X
Justine GantzerInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France.
Charles DarianeDepartment of Urology, Hôpital Européen Georges-Pompidou, AP-HP, Paris-Paris Cité University-U1151 Inserm-INEM, Necker, Paris, France.
Olivier FogelUniversité Paris Descartes, service de rhumatologie, hôpital Cochin, AP-HP, Paris, France.ORCID 0000-0001-7494-2349
Vanessa FriedrichInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France.ORCID 0009-0007-4585-7971
Daniela RovitoInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France.ORCID 0000-0001-5390-5477
Véronique LindnerDépartement de Pathologie, Les Hôpitaux Universitaires de Strasbourg, Strasbourg, 67000, France.
Valentine GilbartInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France.ORCID 0009-0006-8272-7394
Darya YanushkoInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France.ORCID 0000-0001-6223-9015
Sandrine HenriCentre d'Immunologie de Marseille-Luminy, Aix-Marseille Université, Faculté des Sciences de Luminy, Marseille, France.
Daniel MetzgerInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France.ORCID 0000-0002-5555-046X
Gilles LavernyInstitute of Genetics and Molecular and Cellular Biology (IGBMC), Illkirch-Graffenstaden, 67400, France. laverny@igbmc.fr.ORCID 0000-0002-2666-6877

Funding

Agence Nationale de la Recherche (ANR) ANR-10-IDEX-0002Agence Nationale de la Recherche (ANR) ANR-10-IDEX-0002-02Agence Nationale de la Recherche (ANR) ANR-10-LABX-0030-INRTAgence Nationale de la Recherche (ANR) ANR-17-EURE-0023Agence Nationale de la Recherche (ANR) ANR 20-SFRI-0012Institut National Du Cancer (INCa) 18498
6 · The paper itself

Abstract

Prostate cancer (PCa)-related deaths are mainly due to metastasis. The increase in de novo metastatic hormone-naive PCa (mHNPCs) highlights the urgent need for biomarkers and treatment strategies. We report in a cohort of French PCa patients that the levels of vitamin D and of prostate-specific antigen, the progression biomarker used clinically, are negatively associated. However, the impact of vitamin D receptor (VDR) signaling on prostate tumorigenesis remains unclear. Mice with PTEN inactivation in prostatic epithelial cells (PECs) at adulthood (Pten

Indexed as

NeutrophilsProstatic NeoplasmsReceptors, CalcitriolSignal TransductionVitamin DAnimalsCell ProliferationHumansMaleMiceMice, KnockoutOxidative StressPTEN PhosphohydrolasePTEN PhosphohydrolaseReceptors, CalcitriolVitamin D

Identifiers

PMID41957119
PMCPMC13179334

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.