ArticleInternational journal of obesity (2005)2026
Racial and ethnic variations of metabolic indicators associated with childhood obesity: a comparative cross-sectional study.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSusceptibility to adult metabolic diseases varies significantly across ethnicities. Asian adults exhibit elevated risks associated with obesity at lower body mass index (BMI) levels; whether similar patterns occur in pediatric populations remains unclear. This study aimed to evaluate how metabolic indicators associated with childhood obesity vary across diverse racial/ethnic groups.
methodsAge-matched adolescents (12-18 years) from diverse regions across China-along with adolescents from Hispanic, Mexican American (MA), Non-Hispanic Black (NHB), Non-Hispanic White (NHW), and Other ethnic groups from the National Health and Nutrition Examination Survey (NHANES)-were enrolled. Comprehensive demographic, anthropometric and metabolic data-including glycemic parameters, lipid profiles, and insulin resistance indices-were analyzed. Cross-sectional mediation analysis was conducted to explore the potential biological pathways underlying the relationship between obesity (BMI standard deviation score [SDS] as the exposure) and metabolic dysfunction (metabolic indicators as the outcomes), testing cortisol and adrenocorticotropic hormone (ACTH) as potential mediators. Average direct and causal mediation effects were evaluated, with results interpreted as statistical associations consistent with the mediation framework.
resultsThe study included 632 adolescents (55.22% male, mean age 14.51 ± 1.87 years, median BMI 31.55 kg/m
conclusionsThis first multiethnic pediatric metabolic comparison reveals distinct racial/ethnic patterns, with ACTH emerging as a novel mediator in Chinese adolescents. Findings underscore the need for ethnicity-tailored prevention strategies.
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