ArticleNPJ precision oncology2026
CD18-targeted peptide-drug conjugate remodels the immunosuppressive tumor microenvironment of prostate cancer by selective depletion of M2 macrophages.
Article in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Castration-resistant prostate cancer (CRPC) exhibits an immunologically "cold" tumor microenvironment (TME) dominated by M2 tumor-associated macrophages (TAMs), limiting cytotoxic immune infiltration and promoting tumor progression. Targeting M2 macrophages may represent a promising therapeutic strategy. TB511 was synthesized by conjugating a TAM-specific peptide (TAMpep) to a pro-apoptotic d-form KLA peptide via a GGGGS linker. Its structure was characterized by FTIR and CD spectroscopy. Binding affinity to CD18 was determined by biolayer interferometry. A humanized prostate cancer model was established by subcutaneous implantation of PC-3 cells into hCD34
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