ArticleNature communications2026
Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Duet between sugars and hormones: The molecular dialogue fine-tuning hypoxia acclimation in plants.Journal of integrative plant biology · 2026Review
- Prolyl hydroxylase-dependent proteolysis enables the orthogonal hypoxia responses in plants.Nature communications · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Vascular plants and metazoans use selective proteolysis to control responses to hypoxia, although through distinct biochemical mechanisms. The reason for this divergence is puzzling, since the molecular components necessary for both strategies are conserved. To explore the alternative scenario where plants and animals respond to hypoxia through the same mechanisms, we engineer a three-components system aimed to target proteins for degradation in an oxygen dependent manner in Arabidopsis thaliana. When used to control transcription, the synthetic system partially restores hypoxia responsiveness in oxygen-insensitive mutants. Additionally, we demonstrate its potential to regulate growth under flood-induced hypoxia. Our work highlights the use of synthetic biology to reprogramme signalling pathways, providing insights into the evolution of oxygen sensing and offering tools for crop improvement under stress conditions.
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Registered trials
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