ArticleNature communications2026
Vitamin B12 induces memory of predation through vitellogenin provisioning.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nutritional effects on trait inheritance are widespread in animals including human famines, representing some of the most severe environmental influences on organismal phenotypes and can be transmitted over generations. However, the chemical nature of the stimuli inducing such memory remains elusive. The nematode Pristionchus pacificus exhibits mouth-form plasticity including predation and responds to a multigenerational Novosphingobium diet with the induction and transgenerational inheritance of the predatory morph. We show that bacteria-derived vitamin B12 is necessary and sufficient for transgenerational memory. Novosphingobium mutants defective in vitamin B12 production do not induce transgenerational inheritance, but vitamin B12 supplementation can rescue the memory phenotype. Different vitamin B12 concentrations are required for the original induction and subsequent transgenerational inheritance of the predatory morph. This inherited effect acts through increased multigenerational vitellogenin transcription suggesting elevated nutrient provisioning. Consistently, mutants in the vitellogenin receptor Ppa-rme-2 are memory-defective indicating that a vitamin acts through maternal provisioning to progeny. Thus, vitamin B12 induces vitellogenin provisioning to control organismal physiology and behavior.
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