Evidence map›Paper›PMID 41956908›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Refinement of Nucleus Accumbens Neuronal Dynamics during Cocaine Self-Administration Training.

Linjie Jin, Xiguang Qi, Jianwei Liu, William J Wright, Terra A Schall, King-Lun Li, Bo Zeng, Charles Wang, Lirong Wang, Yan Dong

Abstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Linjie JinDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Xiguang QiDepartment of Pharmaceutical Science, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Jianwei LiuDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.ORCID https://orcid.org/0009-0009-4026-045X
William J WrightDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Terra A SchallDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
King-Lun LiDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Bo ZengDepartment of Industrial Engineering, Swanson School of Engineering, University of Pittsburgh, Pennsylvania 15269.
Charles WangCenter for Genomics, School of Medicine, Loma Linda University, Loma Linda, California 92350.
Lirong WangDepartment of Pharmaceutical Science, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15260.
Yan DongDepartment of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260 yandong@pitt.edu.ORCID https://orcid.org/0000-0003-0016-9028

Funding

Glial-mediated synaptic remodeling in drug addictionR01DA040620 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong, ERIC J. NESTLER · 2016 to 2026
$5.3M
Cocaine-induced adaptation in NMDA receptorsR37DA023206 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong · 2018 to 2026
$3.9M
Cocaine-induced Adaptation in NMDA Receptors in Nucleus AccumbensR01DA023206 · NIDA · WASHINGTON STATE UNIVERSITY · PI DONG, YAN · 2008 to 2017
$3.0M
Cellular and Behavioral Function of Astrocytic Dopamine SignalingR01DA060868 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yan Dong · 2024 to 2026
$1.3M
NIDA NIH HHS R01 DA023206NIDA NIH HHS R01 DA040620NIDA NIH HHS R01 DA060868NIDA NIH HHS R37 DA023206
6 · The paper itself

Abstract

Drug addiction is an acquired motivational-behavioral state that begins with drug taking, which is composed of a series of phases, including initial acquisition, stabilization, habituation, and maintenance. In rodent models of cocaine self-administration, the forebrain region nucleus accumbens (NAc) has been critically implicated in the acquisition-maintenance process of drug-taking and drug-seeking behaviors. However, it remains unknown how NAc neurons shift their activity patterns in response to these phasic transitions during cocaine taking. To examine this, we used GCaMP6m-based in vivo Ca

Indexed as

CocaineDopamine Uptake InhibitorsNeuronsNucleus AccumbensAnimalsConditioning, OperantMaleMedium Spiny NeuronsMiceMice, Inbred C57BLSelf AdministrationCocaineDopamine Uptake Inhibitorscocaineensemblemedium spiny neuronsneural dynamicsnucleus accumbensself-administration

Identifiers

PMID41956908
PMCPMC13325609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.