ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026
Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Accumulating evidence indicates that aging is associated with degeneration of neural components in the cochlea even before elevated hearing thresholds indicate hearing loss. Yet, it remains uncertain how such "hidden" hearing loss might shape brain responses to sound. Age-related cochlear decline has been associated with hyperactivity in central auditory pathways, but similar hyperactivity could also arise with age-related brain changes in inhibitory neurotransmission, regardless of peripheral status. Here, we collected an extensive physiological assay of cochlear neural health in an age-diverse cohort of human participants of both sexes (
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