Evidence map›Paper›PMID 41956462›Full record

ArticleACS applied materials & interfaces2026

Leveraging MrkA Display on Self-Assembling Protein Nanoparticles for Enhanced Immune Activation.

Valentina Monaci, Davide Oldrini, Fabiola Giusti, Luigia Cappelli, Roberta Cozzi, Gianina Florentina Belciug, Martina Carducci, Makrina Totsika, Omar Rossi, Francesca Cantini and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Valentina MonaciMagnetic Resonance Center - CERM, University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, Florence 50019, Italy.
Davide OldriniGSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy.
Fabiola GiustiGSK, Via Fiorentina 1, Siena 53100, Italy.
Luigia CappelliGSK, Via Fiorentina 1, Siena 53100, Italy.
Roberta CozziGSK, Via Fiorentina 1, Siena 53100, Italy.
Gianina Florentina BelciugGSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy.
Martina CarducciGSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy.
Makrina TotsikaGSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy.
Omar RossiGSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy.
Francesca CantiniMagnetic Resonance Center - CERM, University of Florence, Via Luigi Sacconi 6, Sesto Fiorentino, Florence 50019, Italy.
Francesca MicoliGSK Vaccines Institute for Global Health (GVGH), Via Fiorentina 1, Siena 53100, Italy.ORCID 0000-0001-8243-3181
Gianmarco GasperiniGSK, Via Fiorentina 1, Siena 53100, Italy.ORCID 0000-0001-5411-7667

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembling protein nanoparticles (NPs) offer a versatile platform to enhance antigen immunogenicity through a multivalent display.

Indexed as

Bacterial ProteinsBacterial VaccinesKlebsiella pneumoniaeNanoparticlesAnimalsAntibodies, BacterialAntigens, BacterialImmunoglobulin GNanovaccinesProtein Subunit VaccinesRabbitsAntibodies, BacterialAntigens, BacterialBacterial ProteinsBacterial VaccinesImmunoglobulin GNanovaccinesProtein Subunit Vaccinesbacterial and mammalian expression systemsgenetic fusionhumoral immune responseKlebsiella pneumoniaeMrkA antigenNMR spectroscopyprotein nanoparticles

Identifiers

PMID41956462
PMCPMC13107372

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.