Evidence map›Paper›PMID 41956382›Full record

ArticleThe Journal of allergy and clinical immunology2026

Heterogeneity and clinical relevance of group 2 innate lymphoid cells subsets in nasal polyps.

Masanori Kidoguchi, Naruhito Iwasaki, Julie A Poposki, Noriko Ogasawara, Aiko Oka, Aiko I Klingler, Lydia Suh, Aditi Agrwal, Junqin Bai, Whitney W Stevens and 13 more

Abstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Masanori KidoguchiDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Division of Otorhinolaryngology and Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Naruhito IwasakiDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Julie A PoposkiDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Noriko OgasawaraDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Aiko OkaDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Otorhinolaryngology, International University of Health and Welfare, Narita, Japan.
Aiko I KlinglerDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Lydia SuhDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Aditi AgrwalDepartment of Otorhinolaryngology, International University of Health and Welfare, Narita, Japan.
Junqin BaiCenter for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Whitney W StevensDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Anju T PetersDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Leslie C GrammerDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Kevin C WelchDepartment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Stephanie S SmithDepartment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Micah JohnsonRegeneron Pharmaceuticals, Tarrytown, NY.
Amr RadwanRegeneron Pharmaceuticals, Tarrytown, NY.
David B ConleyDepartment of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Robert P SchleimerDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Robert C KernDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Bruce K TanDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Mitsuhiro OkanoDepartment of Otorhinolaryngology, International University of Health and Welfare, Narita, Japan.
Shigeharu FujiedaDivision of Otorhinolaryngology and Head & Neck Surgery, Department of Sensory and Locomotor Medicine, Faculty of Medical Science, University of Fukui, Fukui, Japan.
Atsushi KatoDivision of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Center for Human Immunobiology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Department of Otolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Ill. Electronic address: a-kato@northwestern.edu.

Funding

Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Devalingam Mahalingam · 1993 to 2026
$153.9M
Population-based CRS epidemiology: sex differences, natural history, and long-term outcomes based on clinically-defined phenotypes and biologically-based endotypes - GeisingerP01AI145818 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KATO, ATSUSHI · 2019 to 2023
$9.3M
Role of Thymic Stromal Lymphopoietin in Chronic RhinosinusitisR01AI104733 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KATO, ATSUSHI · 2014 to 2018
$1.9M
NCI NIH HHS P30 CA060553NIAID NIH HHS P01 AI145818NIAID NIH HHS R01 AI104733
6 · The paper itself

Abstract

backgroundChronic rhinosinusitis with nasal polyps is characterized by type 2 (T2) inflammation with elevated IL-5 and IL-13. Although group 2 innate lymphoid cells (ILC2s) drive T2 inflammation, their subset diversity and clinical relevance in nasal polyps (NPs) remain unclear.

objectiveWe investigated cellular sources of T2 cytokines, subset heterogeneity of ILC2s, and the relationship between ILC2 subsets and clinical severity in chronic rhinosinusitis with NPs.

methodsILC2s and CD4

resultsUnder ex vivo conditions, NP-derived ILC2s produced higher IL-5 and IL-13 levels than T

conclusionILC2s are one of the important effector populations driving local T2 inflammation in NPs and include 4 subsets with specific clinical associations. Subset-level ILC2 profiling may clarify chronic rhinosinusitis with NP pathophysiology and inform clinical stratification.

Indexed as

LymphocytesLymphocyte SubsetsNasal PolypsRhinosinusitisAdultChronic DiseaseCytokinesFemaleHumansImmunity, InnateMaleMiddle AgedSinusitisTh2 CellsCytokinesgroup 2 innate lymphoid cellsnasal polypsRhinosinusitisRNA sequencingtype 2 immune response

Identifiers

PMID41956382
PMCPMC13195586

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.