Evidence map›Paper›PMID 41956251›Full record

ReviewClinical medicine (London, England)2026

Pitfalls in the pharmacotherapy of hypertension.

Ryan J McNally, Maisarah Amran, Albert Ferro, Carmela Maniero, Stefano Taddei, Luca Faconti

Abstract readReview
In one paragraph

Review in Clinical medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryan J McNallyKing's Health Partners, Centre for Translational Medicine, King's College London, United Kingdom. Electronic address: ryan.mcnally@nhs.net.
Maisarah AmranHypertension Unit, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom. Electronic address: Maisarah.amran@nhs.net.
Albert FerroHypertension Unit, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre, United Kingdom. Electronic address: albert.ferro@kcl.ac.uk.
Carmela ManieroBarts BP of Excellence, Barts NHS Trust, London, United Kingdom. Electronic address: carmen.maniero@nhs.net.
Stefano TaddeiDepartment of Clinical and Experimental Medicine, University of Pisa, Italy. Electronic address: stefano.taddei@unipi.it.
Luca FacontiHypertension Unit, Guy's and St Thomas NHS Foundation Trust, London, United Kingdom; School of Cardiovascular and Metabolic Medicine & Sciences, King's College London British Heart Foundation Centre, United Kingdom. Electronic address: l.faconti@nhs.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the widespread availability of effective antihypertensive medications, blood pressure control remains unsatisfactory in a large number of patients, often due to avoidable dosing misconceptions rather than actual treatment resistance. This educational review aims to facilitate continuing medical education and clinical practice by exploring existing challenges in the pharmacological management of hypertension, focusing on the common drugs prescribed to manage hypertension. After reading this article, clinicians should be able recognise non-linear dose-response relationships, select appropriate medications and doses to achieve better blood pressure control, improve compliance alongside managing side effects that have led to premature discontinuation of beneficial medications. The review further explores how pharmacokinetic properties and patient-specific considerations, such as renal function and ethnicity, might influence choice of antihypertensive medications. This article aims to strengthen clinical choice, medication adherence and long-term management of blood pressure.

Indexed as

Antihypertensive AgentsHypertensionBlood PressureHumansAntihypertensive AgentsAntihypertensiveBlood pressureHypertensionPharmacotherapy

Identifiers

PMID41956251
PMCPMC13137169

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.