Evidence map›Paper›PMID 41956106›Full record

ReviewPhysics in medicine and biology2026

The role of diffusion-weighted MRI in biological image-guided radiation therapy: a roadmap.

Jie Deng, Sirisha Tadimalla, Tyler M Seibert, H Michael Gach, Petra J van Houdt, David A Hormuth Ii, Xun Jia, Jiaren Zou, Christopher C Conlin, Muge Karaman and 15 more

Abstract readReview
In one paragraph

Review in Physics in medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jie DengDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.ORCID 0000-0002-2518-7989
Sirisha TadimallaInstitute of Medical Physics, The University of Sydney, Sydney, Australia.ORCID 0000-0003-2054-055X
Tyler M SeibertDepartment of Radiology, University of California San Diego Health, La Jolla, CA, United States of America.
H Michael GachDepartment of Radiation Oncology, Washington University, St. Louis, MO, United States of America.ORCID 0000-0002-7112-5893
Petra J van HoudtDepartment of Radiation Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
David A Hormuth IiOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas.ORCID 0000-0002-9643-1694
Xun JiaDepartment of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University, Baltimore, MD, United States of America.ORCID 0000-0001-6159-2909
Jiaren ZouDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States of America.ORCID 0000-0002-8356-1967
Christopher C ConlinDepartment of Radiology, University of California San Diego Health, La Jolla, CA, United States of America.ORCID 0000-0003-4509-8702
Muge KaramanCenter for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States of America.ORCID 0000-0002-7080-7307
Junzhong XuInstitute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States of America.ORCID 0000-0001-7895-4232
Jill B De VisDepartment of Radiation Oncology, University of Texas Southwestern Medical Center, Dallas, TX, United States of America.
Lise WeiDepartment of Radiation Oncology, University of Michigan, Ann Arbor, MI, United States of America.
Anna M DornischDepartment of Radiation Medicine and Applied Sciences, University of California San Diego Health, La Jolla, CA, United States of America.
Joseph WeygandDepartment of Radiation Oncology and Applied Sciences, Dartmouth College, Hanover, NH, United States of America.
Yu-Feng WangInstitute of Medical Physics, The University of Sydney, Sydney, Australia.
Daniela ThorwarthSection for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Tübingen, Germany.
Xiaohong Joe ZhouCenter for Magnetic Resonance Research, University of Illinois at Chicago, Chicago, IL, United States of America.ORCID 0000-0003-0793-4925
John C GoreInstitute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Xiaoyu JiangInstitute of Imaging Science, Vanderbilt University Medical Center, Nashville, TN, United States of America.
Taeho KimDepartment of Radiation Oncology, Washington University, St. Louis, MO, United States of America.ORCID 0000-0001-9809-9587
Annette HaworthInstitute of Medical Physics, The University of Sydney, Sydney, Australia.
Heiko EnderlingDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States of America.
Caroline ChungDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, United States of America.
Thomas E YankeelovOden Institute for Computational Engineering and Sciences, The University of Texas at Austin, Austin, Texas.

Funding

A High-End 3 Tesla Human MRI Scanner Dedicated to ResearchS10RR028898 · NCRR · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHOU, XIAOHONG JOE · 2010 to 2010
$2.9M
Probing Intra-voxel Tissue Heterogeneity Using MRIR01EB026716 · NIBIB · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ZHOU, XIAOHONG JOE · 2018 to 2022
$1.7M
Comprehensive Characterization of Breast Tissue Using Multi-modal MRIR21EB032071 · NIBIB · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARAMAN, MUGE M · 2022 to 2024
$640k
NCRR NIH HHS S10 RR028898NIBIB NIH HHS R01 EB026716NIBIB NIH HHS R21 EB032071
6 · The paper itself

Abstract

This roadmap provides a comprehensive framework for integrating diffusion-weighted imaging (DWI) into radiation therapy (RT), with an emphasis on its application in magnetic resonance imaging-guided radiotherapy and its potential for driving biological image-guided adaptive radiotherapy (ART). Developed through collaboration among experts in medical physics, magnetic resonance imaging science, and radiation oncology, the paper aims to bridge disciplinary gaps and foster a shared understanding across scientific, technical, and clinical domains. It benchmarks the current state of DWI in RT, identifies critical challenges, and highlights recent advancements in acquisition, reconstruction, biophysical modeling, quality assurance, clinical validation and translation, as well as emerging concepts. By outlining ongoing efforts and forecasting future developments, this roadmap supports the adoption of DWI as a quantitative imaging biomarker for personalized and ART in precision oncology.

Indexed as

Diffusion Magnetic Resonance ImagingRadiotherapy, Image-GuidedHumansImage Processing, Computer-Assistedbiological image-guided adaptive radiotherapydiffusion weighted MRIimage-guided radiation therapyMRI-guided radiation therapyMRI simulatorMR-LINAC

Identifiers

PMID41956106
PMCPMC13223508

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.