ArticleCell genomics2026
Partitioning genetic pleiotropy within tissue-specific regulatory patterns.
Article in Cell genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
GWAS-associated variants of related complex traits indicate the presence of pleiotropic clusters often related to tissue-specific epigenomic profiles. The authors introduce J-PEP, a novel framework that enables tissue-aware interpretation of complex trait genetic architecture and PEPA, a cross-modal validation metric. J-PEP factorizes trait and tissue data matrices jointly to identify soft clusters of SNPs that capture both pleiotropic and shared epigenomic patterns in tissues, improving both clustering efficiency and mechanistic interpretation.
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