Evidence map›Paper›PMID 41955814›Full record

ArticleBiosensors & bioelectronics2026

Multiplexed nanophotonic sensor arrays for time-resolved biomolecular analysis.

Lisa M Miller, Christopher P Reardon, Kathryn G Leslie, Callum D Silver, Joshua S Male, Clare S Mahon, Thomas F Krauss, Steven Johnson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors & bioelectronics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lisa M MillerSchool of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK. Electronic address: lisa.miller@york.ac.uk.
Christopher P ReardonSchool of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK; Phorest Diagnostics Ltd., School of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK.
Kathryn G LeslieDepartment of Chemistry, Durham University, Durham, DH1 3LE, UK.
Callum D SilverSchool of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK; Phorest Diagnostics Ltd., School of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK.
Joshua S MaleSchool of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK; Phorest Diagnostics Ltd., School of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK.
Clare S MahonDepartment of Chemistry, Durham University, Durham, DH1 3LE, UK.
Thomas F KraussSchool of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK; Phorest Diagnostics Ltd., School of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK.
Steven JohnsonSchool of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK; Phorest Diagnostics Ltd., School of Physics and Technology, University of York, Heslington, York, YO10 5DD, UK. Electronic address: steven.johnson@york.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complex diseases arise from networks of interacting biomolecules, yet most analytical technologies measure only a limited number of interactions simultaneously. Here, we present a chirped guided-mode resonance (cGMR) photonic biosensor array for multiplexed, label-free analysis of biomolecular kinetics across hundreds of sensing sites. The platform integrates 322 photonic sensors on a single chip that are fabricated using a CMOS process ensuring high reproducibility (wavelength sensitivity of 36.8 pixels/nm with a standard deviation of 1.37 pixels/nm). Shifts in the photonic resonance due to molecular binding are recorded using a conventional CMOS camera allowing time-resolved and simultaneous measurements across the entire array. We demonstrate the platform's versatility by monitoring real-time binding of antibodies, aptamers, and synthetic glycopolymers where the parallel measurements reveal distributions of binding responses arising from surface heterogeneity and multivalency that are inaccessible to conventional, single biosensor platforms. As a model, wheat germ agglutinin binding to a GlcNAc-displaying glycopolymer yielded sub-micromolar equilibrium dissociation constants (K

Indexed as

Biosensing TechniquesAntibodiesEquipment DesignProtein BindingTime FactorsWheat Germ AgglutininsAntibodiesWheat Germ AgglutininsBinding kineticsChirped guided-mode resonanceCMOS-Compatible fabricationLabel-free biosensingMultiplexed detectionNanophotonic sensor arraysPoint-of-care diagnostics

Identifiers

PMID41955814
PMCPMC7619026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.