Middle-aged mice show delayed and destabilized food-anticipatory circadian activity under restricted feeding.

Sachi N Ohno, Nana N Takasu, Hitoshi Uchida, Takahiro J Nakamura, Wataru Nakamura, Mitsutaka Sugimura

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Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Sachi N OhnoDepartment of Dental Anesthesiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan; Department of Anesthesiology, Aso Iizuka Hospital, Iizuka, Fukuoka 820-8505, Japan.

Nana N TakasuDepartment of Oral Chrono-Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan.

Hitoshi UchidaDepartment of Oral Chrono-Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan.

Takahiro J NakamuraLaboratory of Animal Physiology, School of Agriculture, Meiji University, Kawasaki, Kanagawa 214-8571, Japan.

Wataru NakamuraDepartment of Oral Chrono-Physiology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8588, Japan. Electronic address: wataru_nakamura@nagasaki-u.ac.jp.

Mitsutaka SugimuraDepartment of Dental Anesthesiology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mice are nocturnal and normally feed during the night; however, timed daily feeding can markedly alter behavioral and physiological rhythms. A well-known example is food-anticipatory activity (FAA), characterized by increased locomotor activity before feeding. In this study, we examined age-related effects on FAA under temporally restricted feeding (RF). Male C57BL/6 J mice aged 12 weeks and 54 weeks were maintained under a 12:12 light-dark cycle and subjected to a 4-h daily RF schedule. Wheel-running activity, feeding timing, intake, and body weight were monitored. Under ad libitum conditions, both age groups exhibited nocturnal activity and feeding. During RF, FAA emerged significantly earlier in young mice than in middle-aged mice. After returning to ad libitum feeding, daytime activity gradually merged into nocturnal rhythms, although some middle-aged mice showed unstable patterns. These results indicate that FAA reflects a circadian system distinct from the suprachiasmatic nucleus and that aging delays and destabilizes its expression.

Indexed as

AgingCircadian RhythmFeeding BehaviorAnimalsBody WeightEatingIntermittent FastingMaleMiceMice, Inbred C57BLMotor ActivityPhotoperiodAgingCircadian rhythmFood-anticipatory activityRestricted feeding

Identifiers

PMID41955671

DOI10.1016/j.jphyss.2026.100071

PMCPMC13091282

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