Evidence map›Paper›PMID 41955543›Full record

ArticleJCO oncology practice2026

Feasibility Study: Early Experiences With a Cancer Center's Virtual Expert Medical Opinion Program.

Allison Lipitz-Snyderman, Susan Chimonas, Brendan Raftery, Lauren Klein Levine, Cole Manship, Sergio Giralt, Tiffany Traina, Steven Sugarman, Benjamin R Roman

Abstract read
In one paragraph

Article in JCO oncology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Allison Lipitz-SnydermanDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-2423-2220
Susan ChimonasDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-7742-5950
Brendan RafteryDepartment of Strategy Innovation and Technology Development, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0009-0000-6648-9484
Lauren Klein LevineDepartment of Strategy Innovation and Technology Development, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0009-0002-4869-0357
Cole ManshipDepartment of Strategy Innovation and Technology Development, Memorial Sloan Kettering Cancer Center, New York, NY.
Sergio GiraltDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-1944-5053
Tiffany TrainaDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-3597-0050
Steven SugarmanDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Benjamin R RomanDepartment of Strategy Innovation and Technology Development, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0003-0947-538X

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

purposeSecond opinion consultations are a promising strategy to identify errors in diagnosis and recommend optimal treatment. Yet, there are geographic barriers. By bringing high-level care to patients where they live, virtual second opinion programs might benefit populations without access to specialty cancer centers. We conducted a feasibility study that examined changes in treatment recommended through a national virtual second opinion program based at a comprehensive cancer center.

methodsMemorial Sloan Kettering Cancer Center (MSK)'s virtual second opinion program was developed via a national cancer employer benefits solution. Each review was conducted by an MSK subspecialist and supported by a digital platform. After conducting the second opinion, subspecialists answered a questionnaire regarding their perceptions of the expected impact of recommended treatment changes. Here, we report findings from December 2023 to November 2024.

resultsThere were 231 cases completed. There were 55% women, with a median age of 56 years. Patients resided across the United States, with 56% from the South. The most common cancer categories were breast, GI and mixed tumor (GMT), and prostate. Cases were reviewed by 76 unique subspecialists. Subspecialists perceived that they made a meaningful change in recommended treatment (expected to affect patient outcomes) in 75 cases (32%). Expected changes included better prognosis/survival (n = 49, 65%), improved short-term morbidity/quality of life/toxicity (n = 36, 48%), or improved long-term morbidity/quality of life/toxicity (n = 49, 65%). There was a higher percent of recommended changes for liquid compared with solid tumor cases (liquid: 15 of 31, 48%; solid: 60 of 200, 30%).

conclusionFindings are helpful for understanding the potential impact of a virtual second opinion program for patients with cancer and for developing strategies to reach underserved communities with geographic access barriers to high-quality cancer care from subspecialists.

Identifiers

PMID41955543
PMCPMC13471743

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.