Evidence map›Paper›PMID 41955477›Full record

ArticleTranslational behavioral medicine2026

Harmonizing adapted interventions across contexts: lessons from harmonizing the World Health Organization's Caregiver Skills Training in Ethiopia and Kenya.

Melissa Washington-Nortey, Eva Mwangome, Mekdes Demissie, Vibian Angwenyi, Victoria Lewa, Eunice Ombech, Yuan Yao, Tigist Eshetu, Rehana Abdurahman, Fikirte Girma and 8 more

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Article in Translational behavioral medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

18 authors.

Melissa Washington-NorteyDepartment of Psychology, Institute of Psychology, Psychiatry and Neuroscience (IoPPN), King's College London, London, United Kingdom.ORCID 0000-0002-8721-1710
Eva MwangomeNeuroscience Group KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya.
Mekdes DemissieDepartment of Psychiatry, College of Health and Medical Sciences, Haramaya University, Dire Dawa, Ethiopia.
Vibian AngwenyiInstitute for Human Development, Aga Khan University, Nairobi, Kenya.
Victoria LewaNeuroscience Group KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya.
Eunice OmbechInstitute for Human Development, Aga Khan University, Nairobi, Kenya.
Yuan YaoNeuroscience Program, The University of Western Ontario, London, Ontario, Canada.
Tigist EshetuCentre for Innovative Drug Development and Therapeutic Trials for Africa, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Rehana AbdurahmanDepartment of Psychiatry (School of Medicine), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Fikirte GirmaDepartment of Psychiatry (School of Medicine), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Ruth TsigebrhanDepartment of Psychiatry (School of Medicine), College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
WHO CST Team
Laura PacioneDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Erica SalomoneUniversity of Milano-Bicocca, Milan, Italy.
Chiara ServiliDepartment of Mental Health, Brain Health and Substance Use, World Health Organization, Geneva, Switzerland.
Amina AbubakarNeuroscience Group KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya.
Charles R NewtonNeuroscience Group KEMRI-Wellcome Trust Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya.
Rosa A HoekstraDepartment of Psychology, Institute of Psychology, Psychiatry and Neuroscience (IoPPN), King's College London, London, United Kingdom.

Funding

National Institute for Health and Care Research NIHR200842
6 · The paper itself

Abstract

backgroundDespite the increasing evidence on the importance of contextual adaptation of interventions, there is limited understanding of how intervention adaptations made for one context can inform adaptation and implementation efforts in others or how to harmonize adapted interventions for use across multiple contexts. PURPOSE: This paper outlines the process used to further adapt and harmonize previous Kenyan and Ethiopian cultural and contextual adaptations of the World Health Organization's Caregiver Skills Training intervention as a case study to propose a framework for similar efforts. It also outlines key lessons learned.

resultsThe Compare, Decide, Develop drafts, and Test and train (CoDDaT) framework is a four-phased, stepwise approach to intervention adaptation and harmonization that involves: (i) comparing available intervention materials and measures across contexts, (ii) deciding in collaboration with key stakeholders on adaptations needed, (iii) developing drafts of harmonized intervention materials and measures, and (iv) testing harmonized intervention materials and measures and training staff. It complements existing implementation frameworks by describing the preparatory phase ahead of implementing an adapted or harmonized project. Critical lessons learned included the importance of accurate documentation, the team's phase-specific size and composition, time management, and the opportunities for network growth and skills development offered by the harmonization process.

conclusionsWe demonstrate how lessons from context-specific adaptations can be applied cross-culturally, while incorporating critical revisions and preserving core intervention components. CoDDaT may inform efforts to adapt and implement interventions to promote health behavior change across contexts and advance the field by challenging interventionists to move beyond single-context-focused adaptations and consider applying adapted interventions to other similar contexts, harmonizing, or refining adapted interventions for more extensive use.

Indexed as

CaregiversEthiopiaHumansKenyaWorld Health OrganizationClinical TrialsContextual AdaptationDevelopmental DisabilitiesImplementation ScienceLow-and Middle-Income CountriesPsychosocial Intervention

Identifiers

PMID41955477
PMCPMC13070423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.