Evidence map›Paper›PMID 41955412›Full record

ArticleChemical research in toxicology2026

Impact of Chemical Quality on High-Throughput in Vitro Assays: A Tox21 Study.

Deborah K Ngan, Lin Ye, Jui-Hua Hsieh, Tuan Xu, Jinghua Zhao, Srilatha Sakamuru, Dingyin Tao, Christopher A LeClair, Tongan Zhao, Anna Rossoshek and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Deborah K NganDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.
Lin YeDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.
Jui-Hua HsiehDivision of Translational Toxicology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709, United States.ORCID 0000-0003-1620-1571
Tuan XuDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.
Jinghua ZhaoDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.
Srilatha SakamuruDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.ORCID 0000-0002-9693-1832
Dingyin TaoDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.ORCID 0000-0001-6531-2740
Christopher A LeClairDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.ORCID 0000-0002-2746-5938
Tongan ZhaoDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.
Anna RossoshekDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.
David M ReifDivision of Translational Toxicology, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, North Carolina 27709, United States.
Anton SimeonovDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.
Menghang XiaDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.ORCID 0000-0001-7285-8469
Ruili HuangDivision of Preclinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States.ORCID 0000-0001-8886-8311

Funding

Intramural NIH HHS Z99 TR999999
6 · The paper itself

Abstract

The Tox21 10K chemical library, an

Indexed as

High-Throughput Screening AssaysSmall Molecule LibrariesBiological AssayHumansQuality ControlTumor Suppressor Protein p53Small Molecule LibrariesTumor Suppressor Protein p53

Identifiers

PMID41955412
PMCPMC13137222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.