ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2026
The interplay between osteosarcopenia and intrinsic capacity: insights and associations with all-cause mortality in the Toledo Study for Healthy Aging.
Ivan Baltasar-Fernandez, Pedro L Valenzuela, Irene Rodríguez-Gómez, Fabio Quiñonez-Bareiro, Luis M Alegre, Konstantinos Prokopidis, Leocadio Rodriguez-Mañas, Ignacio Ara, Oscar Rosas-Carrasco, Lana J Williams and 27 more
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In one paragraphArticle in The journals of gerontology. Series A, Biological sciences and medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
37 authors.
Ivan Baltasar-FernandezGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.ORCID 0000-0003-3434-623X Pedro L ValenzuelaGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.ORCID 0000-0003-1730-3369 Irene Rodríguez-GómezGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.ORCID 0000-0002-1622-7109 Fabio Quiñonez-BareiroGrupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain.
Luis M AlegreGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.ORCID 0000-0002-4502-9275 Konstantinos ProkopidisDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-6264-9388 Leocadio Rodriguez-MañasCentro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain.ORCID 0000-0002-6551-1333 Ignacio AraGENUD Toledo Research Group, Faculty of Sport Sciences, University of Castilla-La Mancha, Toledo, Spain.ORCID 0000-0002-2854-6684 Oscar Rosas-CarrascoGeriatric Assessment Center, Health Department, Ibero-American University, Mexico City, Mexico.ORCID 0000-0002-0564-5882 Lana J WilliamsSchool of Medicine, Deakin IMPACT-The Institute for Mental and Physical Health and Clinical Translation, Geelong, Victoria, Australia.
Julie A PascoSchool of Medicine, Deakin IMPACT-The Institute for Mental and Physical Health and Clinical Translation, Geelong, Victoria, Australia.ORCID 0000-0002-8968-4714 Guy Hajj-BoutrosBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0001-8087-1030 Raman AgnihotramBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Marc SimNutrition & Health Innovation Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia.ORCID 0000-0001-5166-0605 Wayne Lok Ok ChooBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0009-0009-0069-2258 Mahdi ImaniBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0003-1374-5709 Ana M Ayala-CopeteBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0001-7769-431X Julia ChabotDivision of Geriatric Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-1188-7164 Nailton J NetoBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0003-1564-328X Claire Godard-SebillotteDivision of Geriatric Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0003-1477-7489 Howard BergmanDivision of Geriatric Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-7410-1707 Anna AndrianovaRUISS McGill Schouela Centre of Excellence for Sustainable Health of Seniors, Montreal, Quebec, Canada.ORCID 0009-0006-6385-1234 Liang Kung ChenCenter for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei City, Taiwan.ORCID 0000-0002-2387-8508 Hussein SamhatRUISS McGill Schouela Centre of Excellence for Sustainable Health of Seniors, Montreal, Quebec, Canada.ORCID 0009-0003-1681-8974 Ricardo GuerraGraduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil.ORCID 0000-0002-2257-078X Andréa FaustBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
Harmehr SekhonDivision of Geriatric Medicine, Department of Medicine, McGill University, Montreal, Quebec, Canada.ORCID 0000-0002-1967-6858 Emma ConnollyInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Gustavo DuqueBone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.ORCID 0000-0001-8126-0637 Francisco J García-GarcíaGrupo Mixto de Fragilidad y Envejecimiento Exitoso UCLM-SESCAM, Universidad de Castilla-La Mancha-Servicio de Salud de Castilla-La Mancha, Instituto de Investigación Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, Spain.ORCID 0000-0003-3690-6069 Transforming Health and Resilience for Healthy Lives (THRIVE) Project Group
Funding
CIHRMcCall Hutchinson Foundation CB16/10/00456McCall Hutchinson Foundation CB16/10/00464McCall Hutchinson Foundation CB16/10/00477
6 · The paper itselfAbstract
backgroundOsteosarcopenia-the coexistence of osteopenia/osteoporosis and sarcopenia-is associated with numerous adverse health outcomes, but its association with intrinsic capacity (IC) remains unknown. We aimed to explore the associations of osteosarcopenia with IC and all-cause mortality in older adults.
methodsWe conducted a cross-sectional analysis of IC and a prospective analysis of all-cause mortality in 1142 participants from the Toledo Study for Healthy Aging (75.1 ± 6.0 years, 53.1% women). Participants were classified as having no musculoskeletal disorders, osteopenia/osteoporosis, sarcopenia, or osteosarcopenia (DXA- and EWGSOP2-based criteria). IC was operationalized as a composite score integrating locomotion, cognition, psychological, vitality, and sensory domains.
resultsOlder adults with osteosarcopenia exhibited lower total IC (76.6 ± 1.1 points) than those without musculoskeletal disorders (83.7 ± 0.5 points; p < .001) or with osteopenia/osteoporosis (81.3 ± 0.3 points; p < .001), with significant differences also found between the latter groups (p < .001). Specifically, osteosarcopenia was associated with poorer results in the locomotion, cognition, vitality, and sensory domains (all p < .01), but not in the psychological domain. Over a median 6.2-year follow-up, osteosarcopenia-but not osteopenia/osteoporosis-was associated with a higher risk of mortality compared to those without musculoskeletal disorders [HR (95% CI)=1.96 (1.02-3.77); p = .045]. In joint analyses with IC status (high vs low, segregated by the median), this association was specifically observed among participants with osteosarcopenia and low IC [HR = 2.55 (1.31-4.96); p = .004].
conclusionsOsteosarcopenia is associated with lower total IC and impairments across most IC domains. This finding is of clinical relevance, as the combination of this condition and low IC is associated with an increased mortality risk.
Indexed as
Healthy AgingOsteoporosisSarcopeniaAgedAged, 80 and overCause of DeathCross-Sectional StudiesFemaleHumansMaleProspective StudiesAdverse outcomesBoneHealthy agingMuscleOlder adults
Identifiers
PMID41955333
PMCPMC13189856
What OpenQuestion holds
Textmetadata
LicenceCC BY
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