Evidence map›Paper›PMID 41955300›Full record

ArticleThe Journal of medicine and philosophy2026

Egalitarian Justice and the Prevalence Principle in Human Genome Editing.

Douglas MacKay, R Jean Cadigan, Eric Juengst, Alexandra Robinson, Rebecca L Walker

Abstract read
In one paragraph

Article in The Journal of medicine and philosophy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Douglas MacKayUniversity of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
R Jean CadiganUniversity of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Eric JuengstUniversity of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Alexandra RobinsonUniversity of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.
Rebecca L WalkerUniversity of North Carolina, Chapel Hill, Chapel Hill, North Carolina, USA.

Funding

Incidental Enhancement: Addressing a Neglected Policy Issue in Human Genome EditingR01HG010661 · NHGRI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CADIGAN, ROSEMARY JEAN · 2020 to 2023
$3.1M
2023 Annual Conference of the American Society for Bioethics and Humanities in Baltimore2023 Annual Meeting of the Philosophy, Politics, & Economics Society in New OrleansNational Institutes of Health's National Human Genome Research Institute 1R01HG010661- 01A1NHGRI NIH HHS 1R01HG010661- 01A1NHGRI NIH HHS R01 HG010661NIH HHS
6 · The paper itself

Abstract

National and international agencies and organizations are currently considering which ethical principles should inform the governance and use of heritable and non-heritable human genome editing. In this paper, we consider the prevalence principle, according to which heritable and non-heritable genome editing in humans is permissible if and only if it involves the conversion of variants to ones expected to produce traits that are prevalent in the relevant population. This principle thus permits genome editing targeting variants responsible for disease and disability but prohibits genetic enhancement. We consider whether the prevalence principle is supported by considerations of egalitarian justice, as its proponents claim. We argue that it is not and that prominent theories of egalitarian justice instead offer different approaches to genome editing governance. We identify four egalitarian principles policymakers should consider when crafting anticipatory guidance for heritable and non-heritable genome editing.

Indexed as

Gene EditingGenome, HumanSocial JusticeGenetic EnhancementHumansPhilosophy, Medicalegalitarian justicegenetic enhancementgenome editingprevalence principle

Identifiers

PMID41955300
PMCPMC13130085

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.