Evidence map›Paper›PMID 41955163›Full record

ArticleExperimental physiology2026

Paternal sleep deprivation and cardiac dysfunction in offspring: A perspective of myocardial hypertrophy.

Yingying Zhang, Leyao Wang, Jie Wang, Yun Pan, Wen Sun, Zhiwei Zou, Wenlin Bai, Ruiling Fang, Yue Zhang, Ping Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yingying ZhangShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Leyao WangShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Jie WangShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Yun PanShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Wen SunShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Zhiwei ZouShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Wenlin BaiShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Ruiling FangShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Yue ZhangShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Ping ZhangShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Yuanbao ZhangBeijing Key Laboratory of Occupational Safety and Health, Institute of Urban Safety and Environmental Science, Beijing Academy of Science and Technology, Beijing, China.
Lijian LeiShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.
Wenping ZhangShanxi Key Laboratory of Environmental Health Impairment and Prevention, NHC Key Laboratory of Pneumoconiosis, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, China.ORCID https://orcid.org/0000-0002-9314-7460

Funding

Applied Basic Research Program of Shanxi province 20210302123216Applied Basic Research Program of Shanxi province 20210302124038National Science Foundation of China 82103938National Science Foundation of China 82574195Program of Beijing Key Laboratory of Occupational Safety and Health BKL - OSH - 202302Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi 2020L0176Shanxi Province Higher Education "Billion Project" Science and Technology Guidance Project BYBLD002Shenzhen Ripson Institute of Stem Cell Regenerative Medicine Special R&D Project JCYJ202003010103Startup Foundation for Doctors of Shanxi Medical University XD1916Startup Foundation for Doctors of Shanxi Province SD1916Technology Research Foundation of Shanxi Province 201901D211326Technology Research Foundation of Shanxi Province 201901D211335
6 · The paper itself

Abstract

The objective of this work is to assess the effects and potential process of paternal acute sleep deprivation on cardiac function in their offspring. Male and female C57BL/6N mice aged 8-9 weeks (n = 4-5 mice/group) were used. Male mice were selected to construct an acute sleep deprivation model using the modified multiple platform method (MMPM) and mated with normal female mice. After gestation, the weight change of offspring mice was observed and recorded. At the time of 10 weeks, the changes of cardiac function were evaluated by blood pressure, heart rate and echocardiography; cardiac histology and cytopathological changes were observed by haematoxylin-eosin staining; and the molecular mechanism induced by acute paternal sleep deprivation were further elucidated by molecular biological techniques. In the acute sleep deprivation group, male offspring showed significant cardiac hypertrophy, whereas female offspring did not. mRNA levels of GATA binding protein 4 (GATA4) (P < 0.01) and mRNA levels of classic hypertrophic genes, such as atrial natriuretic peptide (ANP) (P < 0.05) and brain natriuretic peptide (BNP) (P < 0.05), increased significantly in the hearts of the acute sleep deprivation group. Paternal acute sleep deprivation may lead to cardiac dysfunction in offspring through cardiac hypertrophy.

Indexed as

CardiomegalySleep DeprivationAnimalsAtrial Natriuretic FactorBlood PressureFemaleGATA4 Transcription FactorHeartHeart RateMaleMiceMice, Inbred C57BLMyocardiumNatriuretic Peptide, BrainPregnancyAtrial Natriuretic FactorGata4 protein, mouseGATA4 Transcription FactorNatriuretic Peptide, Brainacute sleep deprivationcardiac dysfunctionoffspringpaternal

Identifiers

PMID41955163
PMCPMC13131066

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.