ArticleAmerican journal of epidemiology2026
Maternal oxidative stress biomarkers across pregnancy in relation to fetal growth: evidence from the TIDES cohort.
Article in American journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Perinatal Redox Dysregulation in Gestational Tobacco Exposure: Compartment-Specific Composite Indices and Their Association with Birth Outcomes-A Prospective Cohort Study.Antioxidants (Basel, Switzerland) · 2026Article
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15 authors.
Funding
Abstract
Oxidative stress (OS), an imbalance between reactive oxygen species and antioxidants, has been linked to impaired placental function and suboptimal fetal growth, yet trimester-specific associations remain poorly understood. We examined 561 mother-infant pairs from The Infant Development and Environmental Study, measuring maternal urinary biomarkers of DNA oxidation (8-hydroxydeoxyguanosine (8-OHdG)), lipid peroxidation (malondialdehyde (MDA) and F2-isoprostanes), and protein oxidation (dityrosine (diY)) at first and second trimesters. Using generalized linear models, we examined prospective associations between OS and ultrasound-derived growth velocities. Early pregnancy OS biomarkers were persistently associated with reduced second and third trimester growth velocities. First trimester lipid peroxidation markers (8-PGF2α, 15-PGF2α, and 8,15-PGF2α) were associated with slower estimated fetal weight (EFW) growth velocity in both second trimester (-0.81, -0.93, and -1.72 g/week per log-unit increase, respectively) and third trimester (-4.25, -5.60, and -6.74 g/week). Similarly, first trimester 8-OHdG and diY were associated with both second trimester (-1.31 and -1.17 g/week, respectively) and third trimester EFW velocity (-8.01 and -6.75 g/week, respectively). Second trimester 8-OHdG and MDA were associated with slower third trimester EFW velocity (-8.57 and -9.25 g/week, respectively). These results provide novel insights into trimester-specific associations between OS and fetal growth.
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