Evidence map›Paper›PMID 41954859›Full record

ArticleMolecular biomedicine2026

Targeting ANXA1/TRKA axis enhances immunotherapy sensitivity in neural invasion-positive gastric cancer.

Tianlu Jiang, Peng Zhou, Yikai Shen, Jie Lin, Ying Li, Xusheng Shen, Lang Fang, Penghui Xu, Zekuan Xu, Linjun Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tianlu Jiang *Department of General Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University, Wuxi, Jiangsu Province, China.
Peng Zhou *Department of General Surgery, Jiangnan University Medical Center, Wuxi, Jiangsu Province, China.
Yikai Shen *Gastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Jie Lin *Gastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Ying LiDepartment of General Surgery, Hepatobiliary Surgery, Huashan Hospital & Cancer Metastasis Institute, Fudan University, Shanghai, China.
Xusheng ShenGastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Lang FangGastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Penghui XuGastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Zekuan XuGastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. xuzekuan@njmu.edu.cn.
Linjun WangGastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. wanglinjun@njmu.edu.com.
Yiwen XiaGastric Cancer Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China. xiayiwennjmu@163.com.ORCID http://orcid.org/0009-0006-7636-4451

Funding

National Natural Science Foundation of China 82503303National Natural Science Foundation of China No.82273038National Natural Science Foundation of China No.82303168National Natural Science Foundation of China No.82472936National Natural Science Foundation of China No.82473292Natural Science Foundation of Jiangsu Province No. BK20230736Natural Science Foundation of Jiangsu Province No. BK20241984
6 · The paper itself

Abstract

Gastric cancer (GC) remains a leading cause of cancer-related morbidity and mortality worldwide. Neural invasion (NI) is a common pathological behavior that worsens the prognosis in GC. However, the immune microenvironment of neural invasion-positive GC (NI

Indexed as

Annexin A1ImmunotherapyReceptor, trkAStomach NeoplasmsAnimalsCD8-Positive T-LymphocytesCell Line, TumorFemaleHumansMaleMiceNeoplasm InvasivenessT-Cell ExhaustionTumor MicroenvironmentAnnexin A1ANXA1 protein, humanReceptor, trkAANXA1Gastric cancerImmune evasionNeural invasionT cell exhaustionTRKA

Identifiers

PMID41954859
PMCPMC13065939

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.