ReviewHuman cell2026
Exploring the role of protein homeostasis regulation in glycolysis in head and neck tumors.
Review in Human cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
Metabolic reprogramming is a hallmark of cancer. Tumor cells adapt to their environment by modulating glucose, lipid, and amino acid metabolism to supply raw materials for rapid growth and enhance treatment resistance. Among these, glucose metabolic reprogramming is particularly critical. In head and neck tumor cells, glycolysis-derived intermediate metabolites provide biosynthetic precursors and energy necessary for growth, sustaining proliferation and invasion. Additionally, these metabolites can remodel the tumor microenvironment, modulate signaling pathways, and alter tumor phenotypes, further promoting chemoresistance and radioresistance. Protein homeostasis (proteostasis) refers to the dynamic balance of cellular processes involving protein synthesis, folding, modification, transport, and degradation, which is essential for maintaining normal physiological functions. This review aims to explore how proteostasis-regulated degradation pathways-specifically the ubiquitin-proteasome system (UPS) and autophagy-lysosome pathway-modulate glycolysis in head and neck tumors, thereby influencing tumor proliferation and invasion. These insights may provide a theoretical foundation for overcoming treatment resistance and improving prognosis, while also opening new avenues for future therapeutic research in head and neck oncology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.