Evidence map›Paper›PMID 41954787›Full record

Trial reportEuropean journal of pediatrics2026

Randomised crossover trial of neurally adjusted ventilatory assist (NAVA) for neonates with congenital diaphragmatic hernias: the NAN-C study.

Sandeep Shetty, Allan Jenkinson, Grace Poole, Theodore Dassios, Chris Harris, Anay Kulkarni, Donovan Duffy, Anne Greenough

Abstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sandeep ShettyDepartment of Neonatology, St George's University Hospitals NHS Foundation Trust, London, UK. sandeep.shetty@stgeorges.nhs.uk.
Allan JenkinsonDepartment of Neonatology, King's College Hospital NHS Foundation Trust, London, UK.
Grace PooleDepartment of Neonatology, King's College Hospital NHS Foundation Trust, London, UK.
Theodore DassiosDepartment of Neonatology, King's College Hospital NHS Foundation Trust, London, UK.
Chris HarrisDepartment of Neonatology, King's College Hospital NHS Foundation Trust, London, UK.
Anay KulkarniDepartment of Neonatology, St George's University Hospitals NHS Foundation Trust, London, UK.
Donovan DuffyDepartment of Neonatology, St George's University Hospitals NHS Foundation Trust, London, UK.
Anne GreenoughDepartment of Neonatology, King's College Hospital NHS Foundation Trust, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Retrospective studies comparing NAVA to assist control ventilation (ACV) in neonates with congenital diaphragmatic hernia (CDH) have shown that ventilatory mode may improve respiratory parameters. The aim of this study is to determine if infants with CDH studied post-operatively had a lower oxygenation index (OI) on NAVA compared to ACV. This dual-centre randomised cross-over trial compared post-operative NAVA with ACV in infants with CDH. Infants were randomised to receive either NAVA or ACV first in a 1:1 ratio for a 4-h period. At the end of each 4-h period, blood gas analysis was performed and the OI calculated. The inspired oxygen concentration (FiO

Indexed as

Hernias, Diaphragmatic, CongenitalInteractive Ventilatory SupportBlood Gas AnalysisCross-Over StudiesFemaleHumansInfant, NewbornMaleOxygenTreatment OutcomeOxygenCongenital diaphragmatic hernia (CDH)Mechanical ventilationNeonate / Neonatal ventilationNeurally adjusted ventilatory assist (NAVA)Oxygenation index

Identifiers

PMID41954787
PMCPMC13065578

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.