ReviewCurrent HIV/AIDS reports2026
The Changing Spectrum of Cognitive Impairment in People with HIV; Establishment and Updates of the International HIV-Cognition Working Group.
Review in Current HIV/AIDS reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Toward a Unified Neuroimmune Framework for Infection-Associated Psychiatric Disorders.Diseases (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the widespread availability of effective antiretroviral therapy, the spectrum of cognitive impairment in people with HIV has changed from a subcortical dementia to milder impairment. The 2007 criteria for HIV-associated neurocognitive disorders (HAND) provided a methodological approach to classify milder and asymptomatic forms. Research using these criteria found that around 45% of people with HIV had HAND. This does not align with clinical observations that people with HIV supressed on modern treatment generally have good clinical outcomes, including cognitively. HAND criteria have several limitations which may account for an overestimation of prevalence including a high false classification rate, inadequate mitigation of psychosocial confounds to testing of cognitive performance, and the attribution to HIV of multifactorial causes of brain injury. This overestimation can hinder neuro-HIV research, increase anxiety around health outcomes, and worsen stigma and discrimination towards people with HIV. In response an International HIV-Cognition Working Group was established. The group proposed six consensus recommendations towards a new approach, including that HIV-associated brain injury (HABI) - which can be active or legacy - is conceptually separated from other cases of brain injury in people with HIV. The recommendations are aimed at harmonising clinical and research terminology, destigmatising terminology, and providing more accurate information on prevalence and prognosis. Cognitive impairment remains an important complication of HIV, particularly as the population ages, requiring a nuanced approach to classification and management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.