Allergic diseases are more common in children with congenital surgical anomalies or necrotizing enterocolitis compared to the general population.

Rina Tanaka, Ghazale Farjam, Takashi Doi, Suyin A Lum Min, Richard Keijzer

Abstract readComparative Study

In one paragraph

Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Rina TanakaDepartment of Surgery, Division of Pediatric Surgery, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.

Ghazale FarjamDepartment of Surgery, Division of Pediatric Surgery, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.

Takashi DoiDepartment of Pediatric Surgery, Kansai Medical University Hospital, Osaka, Japan.

Suyin A Lum MinDepartment of Surgery, Division of Pediatric Surgery, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada.

Richard KeijzerDepartment of Surgery, Division of Pediatric Surgery, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba and Children's Hospital Research Institute of Manitoba, AE402-820 Sherbrook Street, Winnipeg, MB, R3A 1S1, Canada. rkeijzer@hsc.mb.ca.

Funding

CIHR 178387

6 · The paper itself

Abstract

purposeThis study aimed to assess whether a history of congenital surgical anomaly (CSA) or necrotizing enterocolitis (NEC) increased the prevalence of allergic diseases.

methodsWe performed a retrospective study of children with CSA or NEC from 1991 to 2022. We calculated odds ratios (ORs) of rhinitis, dermatitis, asthma, food and drug allergy, conjunctivitis, urticaria and allergic gastroenteritis identified by ICD-9-CM and ICD-10-CA codes in cases versus date-of-birth matched controls.

resultsWe identified a total of 1168 cases and 11,648 controls. Asthma (OR = 1.62, p < 0.01) and allergic gastroenteritis (OR = 6.66, p < 0.01) were more common in all cases compared to all controls. We compared each surgical anomaly separately: asthma prevalence was higher in esophageal atresia (OR = 3.62, p < 0.01) and NEC cases (OR = 2.69, p < 0.01), while allergic gastroenteritis was higher in congenital diaphragmatic hernia (OR = 13.35, p = 0.04), gastroschisis (OR = 25.91, p = 0.02), Hirschsprung disease (OR = 43.64, p < 0.01), intestinal atresia (OR = 8.86, p = 0.03) and NEC cases (OR = 10.34, p = 0.01).

conclusionWe demonstrated that congenital surgical anomaly patients have a higher risk of asthma and allergic gastroenteritis than the general population. Individual congenital surgical anomalies have specific increased prevalence of certain allergic diseases. Early detection and personalized management of these allergic diseases may reduce long-term incidence and improve treatment.

Indexed as

Enterocolitis, NecrotizingHypersensitivityChildChild, PreschoolFemaleHumansInfantInfant, NewbornMalePrevalenceRetrospective StudiesAllergyCongenital surgical anomalyNecrotizing enterocolitis

Identifiers

PMID41954767

DOI10.1007/s00383-026-06379-6

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