Evidence map›Paper›PMID 41954738›Full record

Observational studyOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Association of frailty trajectories with osteoporosis and hip fracture in an older female population.

Bin Zhang, Jinguang Gu, Ru Lu, Yongli Dong

Erratum issuedAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Bin Zhang *Wangjing Hospital of China Academy of Chinese Medical Sciences, 6 Wangjing South Road, Huajiadi Street, Chaoyang District, Beijing, 100102, China.
Jinguang GuWangjing Hospital of China Academy of Chinese Medical Sciences, 6 Wangjing South Road, Huajiadi Street, Chaoyang District, Beijing, 100102, China.
Ru LuRehabilitation Medicine Department, Cixi People's Hospital, Wenzhou Medical University, Cixi, 315300, China.
Yongli Dong *Wangjing Hospital of China Academy of Chinese Medical Sciences, 6 Wangjing South Road, Huajiadi Street, Chaoyang District, Beijing, 100102, China. dongyongli87@163.com.

Funding

Natural Science Foundation of Beijing Municipality 7252272
6 · The paper itself

Abstract

This study explores the association between frailty trajectories and osteoporosis and hip fractures. Using data from two prospective longitudinal studies-the Health and Retirement Study (HRS) and the English Longitudinal Study of Ageing (ELSA), it finds that frailty status is significantly associated with both osteoporosis and hip fracture.

backgroundFrailty is associated with a variety of chronic diseases, yet there is a lack of research on the association of frailty trajectories with osteoporosis and hip fracture.

methodsThis study used data from two prospective longitudinal cohorts: the Health and Retirement Study (HRS) and the English Longitudinal Study of Ageing (ELSA), with biennial follow-up from 2014 to 2018. A frailty index (FI) was used to measure frailty status, and group-based trajectory modeling was applied to identify four distinct frailty trajectories. Osteoporosis and hip fracture were defined based on self-reported physician diagnosis. Logistic regression models were used to examine associations between frailty trajectories and the two outcomes, with odds ratios (ORs) and 95% confidence intervals (CIs) reported.

resultsA total of 10,207 participants were included (6816 from HRS and 3391 from ELSA). Four groups of frailty trajectories were identified: the "stable robust trajectory" (n = 4949, 48.3%), the "pre-frailty trajectory" (n = 2717, 26.6%), the "moderate frailty trajectory" (n = 1937, 19.0%), and "severe frailty trajectory" (n = 624, 6.1%). Compared to the stable robust trajectory group, the association with osteoporosis was stronger in the multivariate-adjusted pre-frailty trajectory group (OR 1.91, 95% CI 1.69-2.15), the moderate frailty trajectory group (OR 3.02, 95% CI 2.6-3.52), and severe frailty trajectory group (OR 5.39, 95% CI 4.1-7.07), and in the moderate frailty trajectory (OR 2.55, 95% CI 1.68-3.87), and stronger association with hip fracture in the severe frailty trajectory group (OR 6.03, 95% CI 3.2-11.36).

conclusionThese results suggest that frailty status is closely associated with the risk of osteoporosis and hip fracture, with poorer frailty status correlating with a higher risk of osteoporosis and hip fracture.

Indexed as

Frail ElderlyFrailtyHip FracturesOsteoporosisOsteoporotic FracturesAgedAged, 80 and overFemaleGeriatric AssessmentHumansLongitudinal StudiesProspective StudiesRisk FactorsUnited KingdomUnited StatesFrailty trajectoryHip fractureLongitudinal studyOsteoporosisTrajectory modeling of groups

Identifiers

PMID41954738

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.