Recent Progress of N,N-Dimethylformamide (DMF) as Versatile Synthons in Organic Synthesis.

Hao Lu, Meng Yu, Xiaohui Tian, Xiaorong Suo, Xiaomei Hei, Juan Yang, Jianqi Yao, Renhua Qiu

Abstract readReview

In one paragraph

Review in Topics in current chemistry (Cham), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Hao LuNingxia Key Laboratory of Green Catalytic Materials and Technology, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, China. Luhao0605@nxnu.edu.cn.

Meng YuNingxia Key Laboratory of Green Catalytic Materials and Technology, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, China.

Xiaohui TianNingxia Key Laboratory of Green Catalytic Materials and Technology, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, China.

Xiaorong SuoNingxia Key Laboratory of Green Catalytic Materials and Technology, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, China.

Xiaomei HeiNingxia Key Laboratory of Green Catalytic Materials and Technology, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, China.

Juan YangNingxia Key Laboratory of Green Catalytic Materials and Technology, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, China.

Jianqi YaoNingxia Key Laboratory of Green Catalytic Materials and Technology, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, 756000, China. 82021059@nxnu.edu.cn.

Renhua QiuState Key Laboratory of Chemo/Biosensing and Chemometrics, Advanced Catalytic Engineering Research Center of the Ministry of Education, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, China. Renhuaqiu1@hnu.edu.cn.

Funding

the 2025 Ningxia Normal University Institutional Research Project NSDXJGR11the Hu-Xiang High Project of Hunan Province 2018RS3042the Natural Science Foundation of China 21676076, 21878071, 21971060, 22278120, and U24A20539the Natural Science Foundation of the Ningxia Hui Autonomous Region 2025AAC030607the Ningxia Key Laboratory of Green Catalytic Materials and Technology Project 2025SYSYB-08the Ningxia Key Laboratory of Green Catalytic Materials and Technology Project 2025SYSZD-23the Recruitment Program for Foreign Experts of China WQ20164300353the Yuanzhou District Science and Technology R&D Program Yk2025-35

6 · The paper itself

Abstract

N,N-Dimethylformamide (DMF), as an indispensable and versatile reagent in organic synthesis, has evolved from a traditional solvent to a synthetic building block with rich reactivity. Due to its unique molecular structure, DMF can participate in the construction of various complex organic molecules through multiple reaction pathways under different reaction conditions. Accordingly, this review aims to provide a comprehensive and in-depth summary of the latest research progress in organic synthesis using DMF as a versatile synthon, covering all relevant literature reports published between May 1, 2020, and May 1, 2025. Furthermore, in-depth studies of the underlying reaction mechanisms help to precisely understand the essence of DMF's involvement in reactions, thereby providing a solid theoretical foundation for optimizing reaction conditions and developing novel reaction pathways. This review serves as a crucial reference guide for expanding the application scope of DMF in organic synthesis and developing more environmentally friendly organic synthesis methods.

Indexed as

DimethylformamideOrganic ChemicalsChemistry Techniques, SyntheticMolecular StructureDimethylformamideOrganic ChemicalsComplex moleculesN,N-dimethylformamide (DMF)Organic synthesisProgressSynthon

Identifiers

PMID41954731

DOI10.1021/acs.orglett.4c03771

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