Evidence map›Paper›PMID 41954658›Full record

ReviewMikrochimica acta2026

Surface-enhanced Raman spectroscopy combined microfluidic analytical devices for on-site food safety analysis.

Xiang Meng, Junyu Pan, Yiyi Zhang, Danqing Zhu, Xiru Zhang, Manyan Qiu, Yujun Jiang, Wei Zhang, Xianlong Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Mikrochimica acta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiang MengKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China.
Junyu PanKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China.
Yiyi ZhangKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China.
Danqing ZhuKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China.
Xiru ZhangKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China.
Manyan QiuKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China.
Yujun JiangKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China.
Wei ZhangKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China. Zhangwei9791@163.com.
Xianlong ZhangKey Laboratory of Dairy Science, Ministry of Education, Department of Food Science, Northeast Agricultural University, Harbin, 150030, China. xlz425618@163.com.

Funding

Heilongjiang Province Natural Science Foundation of China YQ2025C013National Natural Science Foundation of China 32402229Research Start-up Fund of Northeast Agricultural University 54960612
6 · The paper itself

Abstract

Surface-enhanced Raman spectroscopy (SERS) is a rapid and sensitive analytical tool that has been widely applied in on-site food safety detection. However, challenges remain in improving the reproducibility, sensitivity, and portability of SERS detection. Recently, the integration of SERS with microfluidic analytical devices has attracted increasing attention because microfluidic devices enabled controllable sample handling and improved operational stability for on-site detection. Herein, compared with earlier review, this review emphasized recent progresses in integration strategies and device designs. First of all, we discussed typical approaches for combining SERS with microfluidic platforms, including label-free and label-based formats. Subsequently, the roles of microfluidic devices in SERS-microfluidic analytical devices were discussed. At last, the applications of SERS coupled with microfluidic devices in on-site food safety detection were summarized. Major challenges and future directions were outlined, including improving substrate reproducibility and scalability, minimizing material interference, enhancing robustness in complex food matrices, enabling multiplex and portable detection, and promoting standardization and validation for real-world deployment.

Indexed as

Food AnalysisFood SafetyLab-On-A-Chip DevicesMicrofluidic Analytical TechniquesSpectrum Analysis, RamanFood ContaminationFood safety detectionLabel-free methodsMicrofluidic analytical devicesOn-site detectionSurface-enhanced Raman spectroscopy

Identifiers

PMID41954658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.